Literature DB >> 9888856

Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

R R Gainetdinov1, W C Wetsel, S R Jones, E D Levin, M Jaber, M G Caron.   

Abstract

The mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice lacking the gene encoding the plasma membrane dopamine transporter (DAT) have elevated dopaminergic tone and are hyperactive. This activity was exacerbated by exposure to a novel environment. Additionally, these mice were impaired in spatial cognitive function, and they showed a decrease in locomotion in response to psychostimulants. This paradoxical calming effect of psychostimulants depended on serotonergic neurotransmission. The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants.

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Year:  1999        PMID： 9888856     DOI： 10.1126/science.283.5400.397

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  225 in total

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Review 9.  Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease.

Authors:  Kelly M Lohr; Shababa T Masoud; Ali Salahpour; Gary W Miller
Journal:  Eur J Neurosci       Date:  2016-09-02       Impact factor: 3.386

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Authors:  Evgeny A Budygin
Journal:  Neurosci Lett       Date:  2007-10-11       Impact factor: 3.046
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