Literature DB >> 9888477

Monoclonal antibody ONS-M21 recognizes integrin alpha3 in gliomas and medulloblastomas.

H Kishima1, K Shimizu, K Tamura, Y Miyao, E Mabuchi, E Tominaga, J Matsuzaki, T Hayakawa.   

Abstract

The monoclonal antibody ONS-M21 recognizes an antigen found on the surface of glioma and medulloblastoma cells but does not react with the antigens of normal brain tissue. We purified and identified the 140-kDa protein by means of an antibody-binding affinity column. This 140-kDa antigen has sequences homologous to the amino-terminal region and five parts of the internal domain of integrin alpha3. When the integrin alpha3-related sequences was amplified and used to analyse the mRNA of glioma and medulloblastoma surgical specimens, the transcription level of integrin alpha3 mRNA appeared to be quantitatively correlated with the grade of malignancy. These findings suggest that the ONS-M21 antibody, which reacts with integrin alpha3, might be useful in the diagnosis of gliomas and medulloblastomas.

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Year:  1999        PMID： 9888477      PMCID： PMC2362207          DOI： 10.1038/sj.bjc.6690053

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  28 in total

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2.  Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation.

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4.  Long-term growth suppression of human glioma xenografts by chemoimmunoconjugates of 4-desacetylvinblastine-3-carboxyhydrazide and monoclonal antibody 9.2.27.

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Journal:  Cancer Res       Date:  1992-07-15       Impact factor: 12.701

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6.  Grading of astrocytomas. A simple and reproducible method.

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Authors:  M J Elices; L A Urry; M E Hemler
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Authors:  Y Takada; E Murphy; P Pil; C Chen; M H Ginsberg; M E Hemler
Journal:  J Cell Biol       Date:  1991-10       Impact factor: 10.539

10.  Expression of integrin alpha 3 in gastric and colorectal cancers: its relation to wall contraction and mode of invasion.

Authors:  N Boku; S Yoshida; A Ohtsu; T Fujii; I Koba; Y Oda; M Ryu; T Matsumoto; T Hasebe; K Hosokawa
Journal:  Jpn J Cancer Res       Date:  1995-10
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  4 in total

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4.  Novel monoclonal antibody against integrin α3 shows therapeutic potential for ovarian cancer.

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Journal:  Cancer Sci       Date:  2020-08-07       Impact factor: 6.716
  4 in total

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