Literature DB >> 9887966

Caldesmon: binding to actin and myosin and effects on elementary steps in the ATPase cycle.

J M Chalovich1, A Sen, A Resetar, B Leinweber, R S Fredricksen, F Lu, Y D Chen.   

Abstract

The actin binding protein caldesmon inhibits the actin-activation of myosin ATPase activity. The steps in the cycle of ATP hydrolysis that caldesmon could inhibit include: (1) the binding of myosin to actin, (2) the transition between any two actin-myosin states and (3) the distribution between inactive and active states of actin. The analysis of these possibilities is complicated because caldesmon binds to both myosin and actin and because each caldesmon molecule binds to several actin monomers. This paper reviews procedures for analysing these interactions and summarizes current information on the stability and dynamics of the interaction of caldesmon with actin and myosin. Possible effects of caldesmon on transitions within the ATPase cycle of actomyosin are also discussed.

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Year:  1998        PMID： 9887966     DOI： 10.1046/j.1365-201X.1998.00449.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  9 in total

1.  Acrylodan-labeled smooth muscle tropomyosin reports differences in the effects of troponin and caldesmon in the transition from the active state to the inactive state.

Authors:  Joseph M Chalovich; Evan Lutz; Tamatha Baxley; Mechthild M Schroeter
Journal:  Biochemistry       Date:  2011-06-14       Impact factor: 3.162

2.  Fesselin binds to actin and myosin and inhibits actin-activated ATPase activity.

Authors:  Mechthild M Schroeter; Joseph M Chalovich
Journal:  J Muscle Res Cell Motil       Date:  2005-09-23       Impact factor: 2.698

Review 3.  The latch-bridge hypothesis of smooth muscle contraction.

Authors:  Richard A Murphy; Christopher M Rembold
Journal:  Can J Physiol Pharmacol       Date:  2005-10       Impact factor: 2.273

4.  Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.

Authors:  D M Helfman; E T Levy; C Berthier; M Shtutman; D Riveline; I Grosheva; A Lachish-Zalait; M Elbaum; A D Bershadsky
Journal:  Mol Biol Cell       Date:  1999-10       Impact factor: 4.138

5.  Smooth muscle hypertrophy following partial bladder outlet obstruction is associated with overexpression of non-muscle caldesmon.

Authors:  Erik Y Zhang; Raimund Stein; Shaohua Chang; Yongmu Zheng; Stephen A Zderic; Alan J Wein; Samuel Chacko
Journal:  Am J Pathol       Date:  2004-02       Impact factor: 4.307

6.  The pivotal role of airway smooth muscle in asthma pathophysiology.

Authors:  Annaïg Ozier; Benoit Allard; Imane Bara; Pierre-Olivier Girodet; Thomas Trian; Roger Marthan; Patrick Berger
Journal:  J Allergy (Cairo)       Date:  2011-12-11

7.  Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction.

Authors:  V Hatch; G Zhi; L Smith; J T Stull; R Craig; W Lehman
Journal:  J Cell Biol       Date:  2001-07-30       Impact factor: 10.539

8.  Canine mesenteric artery and vein convey no difference in the content of major contractile proteins.

Authors:  Ilia A Yamboliev; Sean M Ward; Violeta N Mutafova-Yambolieva
Journal:  BMC Physiol       Date:  2002-11-25

9.  Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle.

Authors:  Sandra Pütz; Lisa Sophie Barthel; Marina Frohn; Doris Metzler; Mohammed Barham; Galyna Pryymachuk; Oliver Trunschke; Lubomir T Lubomirov; Jürgen Hescheler; Joseph M Chalovich; Wolfram F Neiss; Manuel Koch; Mechthild M Schroeter; Gabriele Pfitzer
Journal:  J Gen Physiol       Date:  2021-06-11       Impact factor: 4.086
  9 in total

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