Literature DB >> 9887461

[Hemolysis and schizocytosis, malabsorption and the "folate trap": unusual semiological peculiarities associated with vitamin B12 deficiency].

V Jubault1, I De Lacroix-Szmania, J Zittoun, H Jouault, P Lesprit, B Godeau, A Schaeffer.   

Abstract

INTRODUCTION: Hemolysis and red cell fragmentation accompanying vitamin B12 deficiency may misdirect the diagnosis. Signs of malabsorption and abnormalities related to folic acid metabolism characterized by discrepancies between folic acid normal serum levels and erythrocytic folic acid levels may also exist. EXEGESIS: We report the occurrence of hemolysis and red cell fragmentation mimicking microangiopathic hemolytic anemia, malabsorption and folic acid deficiency in the course of vitamin B12 deficiency. Appropriate replacement therapy corrected all abnormalities.
CONCLUSION: An association between hemolysis, malabsorption and folic acid deficiency should lead physicians to search for signs of vitamin B12 deficiency.

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Year:  1998        PMID: 9887461     DOI: 10.1016/s0248-8663(99)80066-6

Source DB:  PubMed          Journal:  Rev Med Interne        ISSN: 0248-8663            Impact factor:   0.728


  3 in total

1.  An Unusual Presentation of Pseudothrombotic Microangiopathy in a Patient with Autoimmune Atrophic Gastritis.

Authors:  Alexandre Malek; Roy Nasnas
Journal:  Case Rep Hematol       Date:  2016-02-25

2.  Pernicious Anemia Associated Cobalamin Deficiency and Thrombotic Microangiopathy: Case Report and Review of the Literature.

Authors:  Farhanah Yousaf; Bruce Spinowitz; Chaim Charytan; Marilyn Galler
Journal:  Case Rep Med       Date:  2017-02-06

3.  Therapeutic dilemma in the management of a patient with the clinical picture of TTP and severe B12 deficiency.

Authors:  Kara Walter; Jennifer Vaughn; Daniel Martin
Journal:  BMC Hematol       Date:  2015-12-01
  3 in total

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