Literature DB >> 9887354

Diagnostics of multidrug resistance in cancer.

G Szakács1, K Jakab, F Antal, B Sarkadi.   

Abstract

Multidrug resistance (MDR), caused by the overexpression of two membrane proteins, MDR1-Pgp and/or MRP, is a major obstacle in the chemotherapy of cancer. The proper laboratory diagnosis of clinical multidrug resistance is still an unresolved question, and this uncertainty, in a vicious cycle, does not allow the correct evaluation of the clinical relevance of the MDR phenomenon. More-over, inefficient MDR diagnostics hinders the development of effective resistance-modulation strategies. In this review, after describing the basic features of the MDR drug pump proteins, the currently employed diagnostic methods are discussed. We suggest that a quantitative, functional method developed in our laboratory may provide a major help in the laboratory assessment of cancer MDR.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9887354     DOI： 10.1007/bf02905214

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  64 in total

Review 1.  ABC transporters: from microorganisms to man.

Authors:  C F Higgins
Journal:  Annu Rev Cell Biol       Date:  1992

Review 2.  Multidrug resistance in human cancer.

Authors:  L J Goldstein; I Pastan; M M Gottesman
Journal:  Crit Rev Oncol Hematol       Date:  1992       Impact factor: 6.312

Review 3.  The biochemistry of P-glycoprotein-mediated multidrug resistance.

Authors:  J A Endicott; V Ling
Journal:  Annu Rev Biochem       Date:  1989       Impact factor: 23.643

Review 4.  The multidrug transporter, a double-edged sword.

Authors:  M M Gottesman; I Pastan
Journal:  J Biol Chem       Date:  1988-09-05       Impact factor: 5.157

5.  Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer.

Authors:  S E Salmon; W S Dalton; T M Grogan; P Plezia; M Lehnert; D J Roe; T P Miller
Journal:  Blood       Date:  1991-07-01       Impact factor: 22.113

6.  Expression of the multidrug resistance P glycoprotein in newly diagnosed adult acute lymphoblastic leukemia: absence of correlation with response to treatment.

Authors:  E Wattel; P Lepelley; A Merlat; C Sartiaux; F Bauters; J P Jouet; P Fenaux
Journal:  Leukemia       Date:  1995-11       Impact factor: 11.528

7.  Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.

Authors:  S P Cole; G Bhardwaj; J H Gerlach; J E Mackie; C E Grant; K C Almquist; A J Stewart; E U Kurz; A M Duncan; R G Deeley
Journal:  Science       Date:  1992-12-04       Impact factor: 47.728

8.  Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

Authors:  K E Noonan; C Beck; T A Holzmayer; J E Chin; J S Wunder; I L Andrulis; A F Gazdar; C L Willman; B Griffith; D D Von Hoff; I B Roninson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

9.  P-glycoprotein (P-170) and CD34 expression in adult acute myeloid leukemia (AML).

Authors:  T Lamy; J E Goasguen; E Mordelet; I Grulois; C Dauriac; B Drenou; J Chaperon; R Fauchet; P Y le Prise
Journal:  Leukemia       Date:  1994-11       Impact factor: 11.528

10.  Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.

Authors:  E Schneider; K H Cowan; H Bader; S Toomey; G N Schwartz; J E Karp; P J Burke; S H Kaufmann
Journal:  Blood       Date:  1995-01-01       Impact factor: 22.113
View more
  14 in total

1.  Multidrug resistance transporters in the olfactory receptor neurons of Xenopus laevis tadpoles.

Authors:  Ivan Manzini; Detlev Schild
Journal:  J Physiol       Date:  2003-01-15       Impact factor: 5.182

2.  Paclitaxel nanocrystals for overcoming multidrug resistance in cancer.

Authors:  Yang Liu; Leaf Huang; Feng Liu
Journal:  Mol Pharm       Date:  2010-06-07       Impact factor: 4.939

3.  Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum.

Authors:  Petra Rohrbach; Cecilia P Sanchez; Karen Hayton; Oliver Friedrich; Jigar Patel; Amar Bir Singh Sidhu; Michael T Ferdig; David A Fidock; Michael Lanzer
Journal:  EMBO J       Date:  2006-06-22       Impact factor: 11.598

4.  Chemosensitization effects of simultaneous suppression of MDR1 and XIAP in multidrug resistant glioma cells.

Authors:  Zhiqing Zhang; Xiaofang Wang; Suping Wang
Journal:  Med Oncol       Date:  2008-01-23       Impact factor: 3.064

5.  Multifunctional tumor-targeted polymer-peptide-drug delivery system for treatment of primary and metastatic cancers.

Authors:  Pooja Chandna; Jayant J Khandare; Elizabeth Ber; Lorna Rodriguez-Rodriguez; Tamara Minko
Journal:  Pharm Res       Date:  2010-08-11       Impact factor: 4.200

Review 6.  MicroRNAs: promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential.

Authors:  Christiane Matuszcak; Joerg Haier; Richard Hummel; Kirsten Lindner
Journal:  World J Gastroenterol       Date:  2014-10-14       Impact factor: 5.742

7.  Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells.

Authors:  Alex M Chen; Min Zhang; Dongguang Wei; Dirk Stueber; Oleh Taratula; Tamara Minko; Huixin He
Journal:  Small       Date:  2009-12       Impact factor: 13.281

8.  The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins.

Authors:  Carlos Luna-Tortós; Bernhard Rambeck; Uwe H Jürgens; Wolfgang Löscher
Journal:  Pharm Res       Date:  2009-11       Impact factor: 4.200

Review 9.  Multidrug Resistance in Mammals and Fungi-From MDR to PDR: A Rocky Road from Atomic Structures to Transport Mechanisms.

Authors:  Narakorn Khunweeraphong; Karl Kuchler
Journal:  Int J Mol Sci       Date:  2021-04-30       Impact factor: 5.923

10.  Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C.

Authors:  Andreas Noack; Sandra Noack; Andrea Hoffmann; Katia Maalouf; Manuela Buettner; Pierre-Olivier Couraud; Ignacio A Romero; Babette Weksler; Dana Alms; Kerstin Römermann; Hassan Y Naim; Wolfgang Löscher
Journal:  PLoS One       Date:  2014-02-04       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.