| Literature DB >> 9885932 |
M R DiSiena1, R Intres, D J Carter.
Abstract
A 34-year-old woman with a history of asthma and oral contraceptive use died suddenly. Autopsy examination showed chronic pulmonary emboli with an acute pulmonary saddle embolus. An underlying congenital thrombophilic disorder was considered. Molecular studies on DNA isolated from blood using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis revealed coagulation factor V Leiden mutation. The incidence of venous thromboembolism in patients with factor V Leiden mutation and associated activated protein C (APC) resistance is discussed.Entities:
Keywords: Biology; Case Studies--women; Contraception; Contraceptive Methods; Diseases; Embolism; Family Planning; Hematological Effects--women; Hemic System; Oral Contraceptives; Physiology; Pulmonary Embolism--women; Research Methodology; Research Report; Studies; Thromboembolism--women; Vascular Diseases; Women
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Year: 1998 PMID： 9885932 DOI： 10.1097/00000433-199812000-00013
Source DB: PubMed Journal: Am J Forensic Med Pathol ISSN： 0195-7910 Impact factor: 0.921