| Literature DB >> 9885787 |
J M Le Mellédo1, S Merani, D Koszycki, F Bellavance, R Palmour, J Gutkowska, S Steinberg, D G Bichet, J Bradwejn.
Abstract
The authors determined whether women with premenstrual dysphoric disorder (PMDD) exhibit a heightened sensitivity to the panicogenic effects of CCK-4 administration and whether this enhanced sensitivity to CCK-4 would vary with the phase of the menstrual cycle at the time of CCK-4 injection. Twenty-one normal controls and 18 PMDD women were randomly assigned to receive the first and second CCK-4 injection during the follicular phase and the luteal phase or vice versa. PMDD women showed a greater anxiety and panic response to CCK-4. These preliminary results suggest that the CCK-B system may play a role in the pathophysiology of PMDD.Entities:
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Year: 1999 PMID： 9885787 DOI： 10.1016/S0893-133X(98)00057-8
Source DB: PubMed Journal: Neuropsychopharmacology ISSN： 0893-133X Impact factor: 7.853