| Literature DB >> 9885573 |
P A Grant1, D Schieltz, M G Pray-Grant, J R Yates, J L Workman.
Abstract
The SAGA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional regulators including Ada, Spt, and TAFII proteins. Here we identify an additional novel subunit of the complex, Tra1, an ATM/PI-3-kinase-related homolog of the human TRRAP cofactor, which is essential for c-Myc and E2F-mediated oncogenic transformation. Mass spectrometry, immunoblotting, and immunoprecipitation experiments confirm the stable association of this protein within SAGA. In addition, the Tra1 protein is a component of at least two other histone acetyltransferase protein complexes. These results indicate a role for Tra1 in the regulation of transcriptional activation through the recruitment of HAT activity to an activator-bound promoter.Entities:
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Year: 1998 PMID： 9885573 DOI： 10.1016/s1097-2765(00)80300-7
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970