Serum selenium levels in multinodular goitre.

Serum selenium levels were measured in 22 patients with a multinodular goitre and compared to 15 normal controls using atomic absorption spectrophotometry. The serum selenium was significantly low in these patients (patients' mean = 9.6 +/- 1.24 mcg/l, versus control mean = 11.7 +/- 1.64 mcg/l and P < 0.005). Serum T4 and T3 were within the normal range in all patients and controls. Their levels correlated positively, though weakly, with the serum selenium levels (r = 0.4 and 0.36, respectively). The control selenium levels in this study were lower than the reported figures from some European countries, but they were close to those from other studies in Egypt. It seems that Egypt is a low selenium area. A wide-scale epidemiological study is recommended, together with the examination of the possible preventive role of selenium supplementation in areas of endemic goitre.