Memory performance in tree shrews: effects of stressful experiences.

Male tree shrews were exposed to alternating non-stressful and stressful conditions, and their memory performance was tested during three different stress periods and after rest periods of various lengths using a modified holeboard. This paradigm circumvents confounding factors, e.g. food or water deprivation, transport to a special testing arena, and excludes the development of automatic cognitive processes by complex memory tasks. In experimental tree shrews, psychosocial conflict caused elevated cortisol levels during the stress phases. While this resulted in an impairment of the stress-sensitive declarative memory during the second stress phase, no memory deficit was found during the first and third stress phase. Despite normalized cortisol levels, significant memory deficits in experimental animals were observed even 10 weeks after the last stressful experience. The alternating order of stressful events revealed that the negative correlation between the level of adrenal steroid hormones and memory performance does not account for the long-lasting effects of psychosocial stress in tree shrews.