PURPOSE: To investigate the value of superior mesenteric artery (SMA) Doppler flow measurements as a marker for disease activity in patients with Crohn's disease. MATERIALS AND METHODS: Duplex Doppler sonographic measurements of SMA bloodflow volume were obtained in 90 patients with suspected or known Crohn's disease in three separate studies. The first study was a pilot study to ascertain the value of Doppler measurements in patients with proven active or inactive disease and to check our performance. In two following studies prospectively a correlation was sought between the independent assessment of Doppler flow measurements and our standard of reference based on clinical history, physical examination, laboratory values, endoscopy, surgery and/or follow-up and prospectively a correlation was sought between Doppler studies and the results of enteroclysis. RESULTS: In all but two patients (study II) adequate measurements of SMA flow were obtained. In the active patient groups the Doppler SMA flow was significantly increased (P < 0.05) compared to the inactive patient groups and the control groups. CONCLUSION: These studies show that SMA Doppler flow measurements can be used as a parameter to assess disease activity in patients with Crohn's disease.
PURPOSE: To investigate the value of superior mesenteric artery (SMA) Doppler flow measurements as a marker for disease activity in patients with Crohn's disease. MATERIALS AND METHODS: Duplex Doppler sonographic measurements of SMA bloodflow volume were obtained in 90 patients with suspected or known Crohn's disease in three separate studies. The first study was a pilot study to ascertain the value of Doppler measurements in patients with proven active or inactive disease and to check our performance. In two following studies prospectively a correlation was sought between the independent assessment of Doppler flow measurements and our standard of reference based on clinical history, physical examination, laboratory values, endoscopy, surgery and/or follow-up and prospectively a correlation was sought between Doppler studies and the results of enteroclysis. RESULTS: In all but two patients (study II) adequate measurements of SMA flow were obtained. In the active patient groups the Doppler SMA flow was significantly increased (P < 0.05) compared to the inactive patient groups and the control groups. CONCLUSION: These studies show that SMA Doppler flow measurements can be used as a parameter to assess disease activity in patients with Crohn's disease.
Authors: Eduardo Garcia Vilela; Henrique Osvaldo da Gama Torres; Fabiana Paiva Martins; Maria de Lourdes de Abreu Ferrari; Marcella Menezes Andrade; Aloísio Sales da Cunha Journal: World J Gastroenterol Date: 2012-03-07 Impact factor: 5.742
Authors: Liliana Chiorean; Dagmar Schreiber-Dietrich; Barbara Braden; Xin-Wu Cui; Reiner Buchhorn; Jian-Min Chang; Christoph F Dietrich Journal: World J Gastroenterol Date: 2015-05-07 Impact factor: 5.742