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Literature DB >> 9882377

Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

A Müllbacher¹, R T Hla, C Museteanu, M M Simon.

Abstract

Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus.

Entities: Gene Species

Mesh：

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Year: 1999 PMID： 9882377 PMCID： PMC103996

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

15 in total

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6. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses.

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Journal: Eur J Immunol Date: 1995-12 Impact factor: 5.532

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Journal: Proc Natl Acad Sci U S A Date: 1996-08-20 Impact factor: 11.205

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Authors: R V Blanden
Journal: J Exp Med Date: 1971-05-01 Impact factor: 14.307

9. In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.

Authors: M M Simon; M Hausmann; T Tran; K Ebnet; J Tschopp; R ThaHla; A Müllbacher
Journal: J Exp Med Date: 1997-11-17 Impact factor: 14.307

10. T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?

Authors: R M Zinkernagel; E Haenseler; T Leist; A Cerny; H Hengartner; A Althage
Journal: J Exp Med Date: 1986-10-01 Impact factor: 14.307

28 in total

1. Creation of killer poxvirus could have been predicted.

Authors: A Müllbacher; M Lobigs
Journal: J Virol Date: 2001-09 Impact factor: 5.103

2. Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.

Authors: Joy Loh; Dori A Thomas; Paula A Revell; Timothy J Ley; Herbert W Virgin
Journal: J Virol Date: 2004-11 Impact factor: 5.103

3. Perforin-deficient CD8+ T cells mediate fatal lymphocytic choriomeningitis despite impaired cytokine production.

Authors: Pernille Storm; Christina Bartholdy; Maria Rathman Sørensen; Jan Pravsgaard Christensen; Allan Randrup Thomsen
Journal: J Virol Date: 2006-02 Impact factor: 5.103

4. Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection.

Authors: Marwan S Abougergi; Sarah J Gidner; David K Spady; Bonnie C Miller; Dwain L Thiele
Journal: Hepatology Date: 2005-01 Impact factor: 17.425

5. Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.

Authors: Adam R Hersperger; Nicholas A Siciliano; Laurence C Eisenlohr
Journal: J Virol Date: 2012-04-24 Impact factor: 5.103