Literature DB >> 9882371

Differential influence of interleukin-12 in the pathogenesis of autoimmune and virus-induced central nervous system demyelination.

J J Bright1, M Rodriguez, S Sriram.   

Abstract

Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) disease are two demyelinating diseases of the central nervous system (CNS) that serve as animal models for multiple sclerosis. Th1 cells are thought to play a role in the pathogenesis of CNS demyelination in both these diseases. We show here the differential influence of interleukin 12, a critical cytokine for the development of Th1 cells in EAE and TMEV disease.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 9882371      PMCID： PMC103990     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  13 in total

Review 1.  Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis.

Authors:  K M Drescher; L R Pease; M Rodriguez
Journal:  Immunol Rev       Date:  1997-10       Impact factor: 12.988

2.  In vivo immunomodulation by monoclonal anti-CD4 antibody. II. Effect on T cell response to myelin basic protein and experimental allergic encephalomyelitis.

Authors:  S Sriram; L Carroll; S Fortin; S Cooper; G Ranges
Journal:  J Immunol       Date:  1988-07-15       Impact factor: 5.422

Review 3.  Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

Authors:  G Trinchieri
Journal:  Annu Rev Immunol       Date:  1995       Impact factor: 28.527

4.  Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis.

Authors:  J J Bright; B F Musuro; C Du; S Sriram
Journal:  J Neuroimmunol       Date:  1998-02       Impact factor: 3.478

5.  Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus.

Authors:  J D Peterson; W J Karpus; R J Clatch; S D Miller
Journal:  Eur J Immunol       Date:  1993-01       Impact factor: 5.532

Review 6.  The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis.

Authors:  T Owens; S Sriram
Journal:  Neurol Clin       Date:  1995-02       Impact factor: 3.806

7.  Study of the mechanisms by which CD4+ T cells contribute to protection in Theiler's murine encephalomyelitis.

Authors:  P Borrow; C J Welsh; A A Nash
Journal:  Immunology       Date:  1993-11       Impact factor: 7.397

8.  CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.

Authors:  P D Murray; K D Pavelko; J Leibowitz; X Lin; M Rodriguez
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

9.  Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis.

Authors:  Cynthia Rivera-Quiñones; Dorian McGavern; James D Schmelzer; Samuel F Hunter; Phillip A Low; Moses Rodriguez
Journal:  Nat Med       Date:  1998-02       Impact factor: 53.440

10.  Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

Authors:  J P Leonard; K E Waldburger; S J Goldman
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307
View more
  8 in total

1.  COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis.

Authors:  Gladson Muthian; Himanshu P Raikwar; Caroline Johnson; Johnson Rajasingh; Amit Kalgutkar; Lawrence J Marnett; John J Bright
Journal:  J Clin Immunol       Date:  2006-01       Impact factor: 8.317

2.  Suppression of neuro inflammation in experimental autoimmune encephalomyelitis by glia maturation factor antibody.

Authors:  Smita Zaheer; Yanghong Wu; Shailendra K Sahu; Asgar Zaheer
Journal:  Brain Res       Date:  2010-12-10       Impact factor: 3.252

3.  Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.

Authors:  Saravanan Kanakasabai; Wanida Chearwae; Crystal C Walline; Wade Iams; Suzanne M Adams; John J Bright
Journal:  Immunology       Date:  2010-04-06       Impact factor: 7.397

4.  Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice.

Authors:  Asgar Zaheer; Smita Zaheer; Shailendra K Sahu; Baoli Yang; Ramon Lim
Journal:  Neurochem Res       Date:  2006-12-07       Impact factor: 3.996

5.  Overexpression of glia maturation factor reinstates susceptibility to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in glia maturation factor deficient mice.

Authors:  Smita Zaheer; Yanghong Wu; Shailendra K Sahu; Asgar Zaheer
Journal:  Neurobiol Dis       Date:  2010-08-07       Impact factor: 5.996

6.  Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte.

Authors:  Gladson Muthian; John J Bright
Journal:  J Clin Immunol       Date:  2004-09       Impact factor: 8.317

Review 7.  Theiler's virus infection: a model for multiple sclerosis.

Authors:  Emilia L Oleszak; J Robert Chang; Herman Friedman; Christos D Katsetos; Chris D Platsoucas
Journal:  Clin Microbiol Rev       Date:  2004-01       Impact factor: 26.132

Review 8.  Pathogenesis of virus-induced immune-mediated demyelination.

Authors:  B S Kim; M A Lyman; B S Kang; H K Kang; H G Lee; M Mohindru; J P Palma
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.