Literature DB >> 9882370

Expression of epstein-barr virus nuclear antigen 1 is associated with enhanced expression of CD25 in the Hodgkin cell line L428.

D Kube1, M Vockerodt, O Weber, K Hell, J Wolf, B Haier, F A Grässer, N Müller-Lantzsch, E Kieff, V Diehl, H Tesch.   

Abstract

Epstein-Barr virus is associated with several human malignancies including Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease (HD). To examine the effect of Epstein-Barr virus nuclear antigen 1 (EBNA-1) in the pathogenesis of HD, we transfected the gene into the HD cell line L428. EBNA-1 expression was associated with significantly enhanced CD25 expression (interleukin 2 [IL-2]-receptor alpha chain) in transient and stably transfected L428 cells but did not affect the expression of IL-2 receptor beta and gamma chains. There was no up-regulation of the B-cell activation molecules CD23, CD30, CD39, CD40, CD44, CD71, and CD54 (intercellular adhesion molecule 1) or enhanced production of IL-6, IL-10, lymphotoxin alpha, and the soluble form of CD25. Stable EBNA-1-expressing L428 cells were nontumorigenic in SCID mice but showed enhanced lymphoma development in nonobese diabetic-SCID mice compared to mock-transfected cells.

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Year:  1999        PMID： 9882370      PMCID： PMC103989     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  Growth of Hodgkin cell lines in severely combined immunodeficient mice.

Authors:  C von Kalle; J Wolf; A Becker; A Sckaer; M Munck; A Engert; U Kapp; C Fonatsch; D Komitowski; W Feaux de Lacroix
Journal:  Int J Cancer       Date:  1992-12-02       Impact factor: 7.396

2.  Production of multiple cytokines by Hodgkin's disease derived cell lines.

Authors:  S Klein; M Jücker; V Diehl; H Tesch
Journal:  Hematol Oncol       Date:  1992 Nov-Dec       Impact factor: 5.271

3.  Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease.

Authors:  F A Grässer; P G Murray; E Kremmer; K Klein; K Remberger; W Feiden; G Reynolds; G Niedobitek; L S Young; N Mueller-Lantzsch
Journal:  Blood       Date:  1994-12-01       Impact factor: 22.113

4.  Expression of epstein-barr virus encoded nuclear antigen 1 in benign and malignant tissues harbouring EBV.

Authors:  J J Oudejans; D F Dukers; N M Jiwa; A J van den Brule; F A Grässer; P C de Bruin; A Horstman; W Vos; J van Gorp; J M Middeldorp; C J Meijer
Journal:  J Clin Pathol       Date:  1996-11       Impact factor: 3.411

5.  Characterization of interleukin 2 receptors on B-cell chronic lymphocytic leukemia cells.

Authors:  V Tsilivakos; A Tsapis; S Kakolyris; P Iliakis; M Perraki; V Georgoulias
Journal:  Leukemia       Date:  1994-09       Impact factor: 11.528

Review 6.  Does IL-2 receptor expression and secretion in chronic B-cell leukemia have a role in down-regulation of the immune system?

Authors:  J Burton; N E Kay
Journal:  Leukemia       Date:  1994-01       Impact factor: 11.528

7.  Hodgkin and Reed-Sternberg cells express interleukin 6 and interleukin 6 receptors.

Authors:  H Tesch; M Jücker; S Klein; H Abts; A Günther; G R Krueger; V Diehl
Journal:  Leuk Lymphoma       Date:  1992-07

8.  Expression of interleukin-2R alpha and interleukin-2R beta in Hodgkin's disease.

Authors:  H Tesch; A Günther; H Abts; M Jücker; S Klein; G R Krueger; V Diehl
Journal:  Am J Pathol       Date:  1993-06       Impact factor: 4.307

9.  EBNA-1, the major nuclear antigen of Epstein-Barr virus, resembles 'RGG' RNA binding proteins.

Authors:  D K Snudden; J Hearing; P R Smith; F A Grässer; B E Griffin
Journal:  EMBO J       Date:  1994-10-17       Impact factor: 11.598

10.  Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.

Authors:  E M Deacon; G Pallesen; G Niedobitek; J Crocker; L Brooks; A B Rickinson; L S Young
Journal:  J Exp Med       Date:  1993-02-01       Impact factor: 14.307
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  19 in total

1.  Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth.

Authors:  M S Kang; S C Hung; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-04       Impact factor: 11.205

2.  Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1.

Authors:  Hong Wu; Priya Kapoor; Lori Frappier
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

3.  Epstein-Barr virus small RNAs potentiate tumorigenicity of Burkitt lymphoma cells independently of an effect on apoptosis.

Authors:  I K Ruf; P W Rhyne; C Yang; J L Cleveland; J T Sample
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

4.  Is the Epstein-Barr virus EBNA-1 protein an oncogen?

Authors:  Thomas F Schulz; Susann Cordes
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-11       Impact factor: 11.205

5.  EBNA1 regulates cellular gene expression by binding cellular promoters.

Authors:  Allon Canaan; Izhak Haviv; Alexander E Urban; Vincent P Schulz; Steve Hartman; Zhengdong Zhang; Dean Palejev; Albert B Deisseroth; Jill Lacy; Michael Snyder; Mark Gerstein; Sherman M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-22       Impact factor: 11.205

6.  Repression of Epstein-Barr virus EBNA-1 gene transcription by pRb during restricted latency.

Authors:  I K Ruf; J Sample
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

7.  Inflammatory pseudotumour-like follicular dendritic cell tumour of the spleen.

Authors:  Raisuke Nishiyama; Satoshi Baba; Yoichi Watahiki; Hirotoshi Maruo
Journal:  BMJ Case Rep       Date:  2015-03-12

8.  The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold.

Authors:  Sibille Humme; Gilbert Reisbach; Regina Feederle; Henri-Jacques Delecluse; Kristine Bousset; Wolfgang Hammerschmidt; Aloys Schepers
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-28       Impact factor: 11.205

9.  Epstein-Barr virus infection transforms CD25+ B cells into antibody-secreting cells in rheumatoid arthritis patients.

Authors:  Mikael Brisslert; Maria Rehnberg; Maria I Bokarewa
Journal:  Immunology       Date:  2013-12       Impact factor: 7.397

10.  Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.

Authors:  Robert Valentine; Christopher W Dawson; Chunfang Hu; Khilan M Shah; Thomas J Owen; Kathryn L Date; Sonia P Maia; Jianyong Shao; John R Arrand; Lawrence S Young; John D O'Neil
Journal:  Mol Cancer       Date:  2010-01-05       Impact factor: 27.401
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