The prime role of plasma membrane cholesterol in the pathogenesis of immune evasion and clinical manifestations of falciparum malaria.

The pathogenesis of falciparum malaria, with its immune evasion, mechanism of immune suppression and immunological inertia, the cause of its preferential incidence in children and pregnant mothers, and the pathological basis of clinical manifestations, are discussed from biochemical, biophysical and immunological perspectives. Sequestration and recrudescence are highlighted as the evolved means by which malaria parasites survive. These discussions are based on a novel hypothesis that changes in the lipid matrix fluidity of plasma membrane, through alterations of cholesterol and phospholipid content and variation in body temperature, significantly affect the membrane functions of cells. The pathogenesis of aggressive behavior in cerebral malaria is postulated to be different from that of coma, and complicated pregnancy in malaria is also discussed as a multifactorial condition wherein hypocholesterolemia, resulting from increased membrane biogenesis of multiplying parasites, is the common underlying factor.