Literature DB >> 9881494

Significance of angiogenic factors in liver metastatic tumors originating from colorectal cancers.

A Nanashima1, M Ito, I Sekine, S Naito, H Yamaguchi, T Nakagoe, H Ayabe.   

Abstract

We examined the expression of vascular endothelial growth factor (VEGF) and microvessel counts expressed by CD34 staining in 39 patients with primary and 44 patients with metastatic liver tumors of metastatic colorectal carcinoma, and 29 patients with nonmetastatic colorectal carcinoma as control in order to determine their value in the evaluation of prognosis and recurrence after hepatectomy. Microvessel counts in primary colorectal carcinomas of the metastatic group were significantly higher than those in control (P<0.05). Neither factor correlated with any clinicopathological feature of primary or metastatic liver carcinomas. Higher microvessel counts in metastatic liver tumors tended to be associated with a shorter disease-free interval to second recurrence in the remaining liver (P = 0.069) and were significantly associated with poor prognosis after hepatectomy (P<0.05). We conclude that microvessel count is an important marker of liver metastasis and prognosis in patients with colorectal carcinoma treated with hepatectomy.

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Year:  1998        PMID： 9881494     DOI： 10.1023/a:1026643009152

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  25 in total

1.  Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinomas.

Authors:  N Tanigawa; H Amaya; M Matsumura; T Shimomatsuya; T Horiuchi; R Muraoka; M Iki
Journal:  Cancer Res       Date:  1996-06-01       Impact factor: 12.701

Review 2.  Angiogenesis in colorectal cancer.

Authors:  T J Saclarides
Journal:  Surg Clin North Am       Date:  1997-02       Impact factor: 2.741

3.  Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.

Authors:  F Ishikawa; K Miyazono; U Hellman; H Drexler; C Wernstedt; K Hagiwara; K Usuki; F Takaku; W Risau; C H Heldin
Journal:  Nature       Date:  1989-04-13       Impact factor: 49.962

4.  Tumor angiogenesis and mode of metastasis in patients with colorectal cancer.

Authors:  N Tanigawa; H Amaya; M Matsumura; C Lu; A Kitaoka; K Matsuyama; R Muraoka
Journal:  Cancer Res       Date:  1997-03-15       Impact factor: 12.701

5.  Gain of chromosome 20 is a frequent aberration in liver metastasis of colorectal cancers.

Authors:  A Nanashima; H Yamaguchi; T Yasutake; T Sawai; H Kusano; Y Tagawa; T Nakagoe; H Ayabe
Journal:  Dig Dis Sci       Date:  1997-07       Impact factor: 3.199

6.  Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis.

Authors:  S M Kang; K Maeda; N Onoda; Y S Chung; B Nakata; Y Nishiguchi; M Sowa
Journal:  Int J Cancer       Date:  1997-10-21       Impact factor: 7.396

7.  Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

Authors:  N Weidner; P R Carroll; J Flax; W Blumenfeld; J Folkman
Journal:  Am J Pathol       Date:  1993-08       Impact factor: 4.307

8.  Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor.

Authors:  M Miettinen; A E Lindenmayer; A Chaubal
Journal:  Mod Pathol       Date:  1994-01       Impact factor: 7.842

Review 9.  Molecular mechanisms of developmental and tumor angiogenesis.

Authors:  K H Plate; G Breier; W Risau
Journal:  Brain Pathol       Date:  1994-07       Impact factor: 6.508

10.  Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

Authors:  M S O'Reilly; L Holmgren; Y Shing; C Chen; R A Rosenthal; M Moses; W S Lane; Y Cao; E H Sage; J Folkman
Journal:  Cell       Date:  1994-10-21       Impact factor: 41.582
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  11 in total

1.  Prognostic factors in hepatic metastases of colorectal carcinoma: immunohistochemical analysis of tumor biological factors.

Authors:  A Nanashima; H Yamaguchi; T Sawai; E Yamaguchi; H Kidogawa; S Matsuo; T Yasutake; T Tsuji; M Jibiki; T Nakagoe; H Ayabe
Journal:  Dig Dis Sci       Date:  2001-08       Impact factor: 3.199

2.  Upregulation of vascular endothelial growth factor by hydrogen peroxide in human colon cancer.

Authors:  Jian-Wei Zhu; Bao-Ming Yu; Yu-Bao Ji; Ming-Hua Zheng; Dong-Hua Li
Journal:  World J Gastroenterol       Date:  2002-02       Impact factor: 5.742

Review 3.  Targeted therapy in rectal cancer.

Authors:  Christopher G Willett; Dan G Duda; Brian G Czito; Johanna C Bendell; Jeffrey W Clark; Rakesh K Jain
Journal:  Oncology (Williston Park)       Date:  2007-08       Impact factor: 2.990

4.  Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma.

Authors:  Atsushi Nanashima; Toshiyuki Nakayama; Yorihisa Sumida; Takafumi Abo; Hiroaki Takeshita; Kenichirou Shibata; Shigekazu Hidaka; Terumitsu Sawai; Toru Yasutake; Takeshi Nagayasu
Journal:  World J Gastroenterol       Date:  2008-08-21       Impact factor: 5.742

5.  Macrophage migration inhibitory factor promotes colorectal cancer.

Authors:  Xing-Xiang He; Ken Chen; Jun Yang; Xiao-Yu Li; Huo-Ye Gan; Cheng-Yong Liu; Thomas R Coleman; Yousef Al-Abed
Journal:  Mol Med       Date:  2008-11-10       Impact factor: 6.354

6.  Targeting the tumor microenvironment: focus on angiogenesis.

Authors:  Fengjuan Fan; Alexander Schimming; Dirk Jaeger; Klaus Podar
Journal:  J Oncol       Date:  2011-08-24       Impact factor: 4.375

7.  Neoadjuvant treatment in rectal cancer: actual status.

Authors:  Ingrid Garajová; Stefania Di Girolamo; Francesco de Rosa; Jody Corbelli; Valentina Agostini; Guido Biasco; Giovanni Brandi
Journal:  Chemother Res Pract       Date:  2011-09-21

8.  Value of DCE-MRI and FDG-PET/CT in the prediction of response to preoperative chemotherapy with bevacizumab for colorectal liver metastases.

Authors:  S De Bruyne; N Van Damme; P Smeets; L Ferdinande; W Ceelen; J Mertens; C Van de Wiele; R Troisi; L Libbrecht; S Laurent; K Geboes; M Peeters
Journal:  Br J Cancer       Date:  2012-05-17       Impact factor: 7.640

9.  Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature.

Authors:  G Des Guetz; B Uzzan; P Nicolas; M Cucherat; J-F Morere; R Benamouzig; J-L Breau; G-Y Perret
Journal:  Br J Cancer       Date:  2006-06-19       Impact factor: 7.640

10.  Effect of manipulation of primary tumour vascularity on metastasis in an adenocarcinoma model.

Authors:  M M Davies; P Mathur; P Carnochan; S Saini; T G Allen-Mersh
Journal:  Br J Cancer       Date:  2002-01-07       Impact factor: 7.640
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