R W Baumgartner1, H P Mattle, G Schroth. 1. Department of Neurology, University Hospital of Zürich, Switzerland. Strusbmg@neurol.unizh.ch
Abstract
BACKGROUND AND PURPOSE: A favorable risk-benefit ratio for warfarin compared with aspirin has been reported for the prevention of major vascular events in symptomatic >/=50% intracranial stenoses. Transcranial color-coded duplex sonography (TCCS) criteria providing an accurate detection of >/=50% and <50% stenoses of the anterior, middle, and posterior cerebral arteries and basilar and vertebral arteries were evaluated retrospectively with angiography used as the standard of reference. METHODS: Prospectively collected TCCS, extracranial color-coded duplex sonography, and intra-arterial digital subtraction angiography data of 310 patients were reviewed. The patients had angiography for confirmation of symptomatic extracranial >/=70% carotid stenoses, symptomatic stenoses (peak systolic velocity higher than the corresponding mean value +2 SDs of 104 normal subjects), and occlusions of the middle cerebral or basilar artery previously assessed by ultrasound. The sonographer was not aware of angiographic findings. RESULTS: TCCS would have detected all 31 of >/=50% intracranial stenoses with 1 false-positive and 35 of 38 <50% stenoses with 3 false-positives. One of 69 stenoses (1%) and 280 of 2741 normal arteries (10%) were missed because of inadequate insonation windows. The corresponding peak systolic velocity cutoffs for >/=50%/<50% stenoses were >/=155/>/=120 cm/s (anterior cerebral artery), >/=220/>/=155 cm/s (middle cerebral artery), >/=145/>/=100 cm/s (posterior cerebral artery), >/=140/>/=100 cm/s (basilar artery), and >/=120/>/=90 cm/s (vertebral artery). CONCLUSIONS: TCCS may reliably assess >/=50% and <50% basal cerebral artery narrowing and prove useful for noninvasive management of patients with symptomatic intracranial stenoses.
BACKGROUND AND PURPOSE: A favorable risk-benefit ratio for warfarin compared with aspirin has been reported for the prevention of major vascular events in symptomatic >/=50% intracranial stenoses. Transcranial color-coded duplex sonography (TCCS) criteria providing an accurate detection of >/=50% and <50% stenoses of the anterior, middle, and posterior cerebral arteries and basilar and vertebral arteries were evaluated retrospectively with angiography used as the standard of reference. METHODS: Prospectively collected TCCS, extracranial color-coded duplex sonography, and intra-arterial digital subtraction angiography data of 310 patients were reviewed. The patients had angiography for confirmation of symptomatic extracranial >/=70% carotid stenoses, symptomatic stenoses (peak systolic velocity higher than the corresponding mean value +2 SDs of 104 normal subjects), and occlusions of the middle cerebral or basilar artery previously assessed by ultrasound. The sonographer was not aware of angiographic findings. RESULTS: TCCS would have detected all 31 of >/=50% intracranial stenoses with 1 false-positive and 35 of 38 <50% stenoses with 3 false-positives. One of 69 stenoses (1%) and 280 of 2741 normal arteries (10%) were missed because of inadequate insonation windows. The corresponding peak systolic velocity cutoffs for >/=50%/<50% stenoses were >/=155/>/=120 cm/s (anterior cerebral artery), >/=220/>/=155 cm/s (middle cerebral artery), >/=145/>/=100 cm/s (posterior cerebral artery), >/=140/>/=100 cm/s (basilar artery), and >/=120/>/=90 cm/s (vertebral artery). CONCLUSIONS: TCCS may reliably assess >/=50% and <50% basal cerebral artery narrowing and prove useful for noninvasive management of patients with symptomatic intracranial stenoses.
Authors: J U Harrer; M Nedelmann; J Eyding; M Ritter; U Schminke; G Schulte-Altedorneburg; M Köhrmann; F Schlachetzki Journal: Med Klin Intensivmed Notfmed Date: 2012-10-17 Impact factor: 0.840