| Literature DB >> 9880084 |
B Borowsky1, M W Walker, L Y Huang, K A Jones, K E Smith, J Bard, T A Branchek, C Gerald.
Abstract
We present the molecular cloning and characterization of the human galanin receptor, hGALR2. hGALR2 shares 85%, 39%, and 57% amino acid identities to rGALR2, hGALR1, and hGALR3, respectively. hGALR2, along with rGALR2, can be distinguished from the other cloned galanin receptors by a tolerance for both N-terminal extension and C-terminal deletion of galanin, as well as by a primary signaling mechanism involving phosphatidyl inositol hydrolysis and calcium mobilization. By RT-PCR, GALR2 mRNA was abundant in human hippocampus, hypothalamus, heart, kidney, liver, and small intestine. A weak GALR2 mRNA signal was detected in human retina, and no signal was detected in cerebral cortex, lung, spleen, stomach, or pituitary.Entities:
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Year: 1998 PMID： 9880084 DOI： 10.1016/s0196-9781(98)00133-8
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750