Literature DB >> 9880016

Cis-acting elements in the lytic origin of DNA replication of Marek's disease virus type 1.

A Katsumata1, A Iwata, S Ueda.   

Abstract

The replication origin of Marek's disease virus (MDV) type 1 was analysed by using a transient replication assay with plasmids containing various fragments of MDV strain Md5 genomic DNA. Plasmid pMBH, containing the BamHI-H fragment, showed replication activity in MDV-infected chicken embryonic fibroblasts (CEF). By deletion analysis of pMBH, two regions, the promoter-enhancer region of the MDV pp38 gene and the 132 bp tandem direct repeat, were shown to be required for replication activity. Replication of pMBH was not observed in uninfected CEF, suggesting that a trans-acting factor(s) encoded by the MDV genome was necessary for replication.

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Year:  1998        PMID： 9880016     DOI： 10.1099/0022-1317-79-12-3015

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  6 in total

1.  Expansion of a unique region in the Marek's disease virus genome occurs concomitantly with attenuation but is not sufficient to cause attenuation.

Authors:  R F Silva; S M Reddy; B Lupiani
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

2.  Marek's disease virus unique genes pp38 and pp24 are essential for transactivating the bi-directional promoters for the 1.8 kb mRNA transcripts.

Authors:  Jiabo Ding; Zhizhong Cui; Lucy F Lee
Journal:  Virus Genes       Date:  2007-07-06       Impact factor: 2.332

3.  Functional characterization of Marek's disease virus (MDV) origin-binding protein (OBP): analysis of its origin-binding properties.

Authors:  T F Wu; H H Chen; H Wu
Journal:  Virus Genes       Date:  2001       Impact factor: 2.332

4.  The role of pp38 in regulation of Marek's disease virus bi-directional promoter between pp38 and 1.8-kb mRNA.

Authors:  Jiabo Ding; Zhizhong Cui; Lucy F Lee; Xiaoping Cui; Sanjay M Reddy
Journal:  Virus Genes       Date:  2006-04       Impact factor: 2.332

5.  Alterations of the MDV oncogenic regions in an MDV transformed lymphoblastoid cell line.

Authors:  E Le Rouzic; P Thoraval; M Afanassieff; Y Cherel; G Dambrine; B Perbal
Journal:  Mol Pathol       Date:  2002-08

6.  The construction and characterization of the bi-directional promoter between pp38 gene and 1.8-kb mRNA transcripts of Marek's disease viruses.

Authors:  Ruiai Chen; Jiabo Ding; Bin Wang
Journal:  Virol J       Date:  2009-11-30       Impact factor: 4.099
  6 in total

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