Literature DB >> 9879534

Anti-viral effect of interferon-alpha on bovine viral diarrhea virus.

H Sentsui1, R Takami, T Nishimori, K Murakami, T Yokoyama, Y Yokomizo.   

Abstract

To get basic information to control persistent virus infection among domestic animals by cytokines, the antiviral activity of four natural human cytokines against bovine viral diarrhea virus (BVDV) was evaluated. Normal bovine peripheral blood mononuclear leukocytes (PBML) and fetal bovine muscular cells (FBMC) were treated with varying doses of human interferon (IFN)-alpha, IFN-gamma, tumor necrosis factor (TNF)-alpha and TNF-beta. The antiviral activity in treated cells was measured by the titration of virus infectivity in comparison with non-treated controls. IFN-alpha significantly suppressed virus growth in both PBML and FBMC. The growth of two cytopathogenic and two noncytopathogenic strains was suppressed in the presence of more than 10(3) u/ml of IFN-alpha. Addition of either TNF-alpha or TNF-beta to IFN-alpha did not potentiate the suppressive effect. IFN-alpha also suppressed the replication of BVDV in PBML from cattle persistently infected with BVDV.

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Year:  1998        PMID： 9879534     DOI： 10.1292/jvms.60.1329

Source DB:  PubMed          Journal:  J Vet Med Sci        ISSN： 0916-7250            Impact factor:   1.267


  6 in total

1.  "Self" and "nonself" manipulation of interferon defense during persistent infection: bovine viral diarrhea virus resists alpha/beta interferon without blocking antiviral activity against unrelated viruses replicating in its host cells.

Authors:  Matthias Schweizer; Philippe Mätzener; Gabriela Pfaffen; Hanspeter Stalder; Ernst Peterhans
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

2.  Establishment of a subgenomic replicon for bovine viral diarrhea virus in Huh-7 cells and modulation of interferon-regulated factor 3-mediated antiviral response.

Authors:  Nigel Horscroft; Dan Bellows; Israrul Ansari; Vicky C H Lai; Shannon Dempsey; Delin Liang; Ruben Donis; Weidong Zhong; Zhi Hong
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

3.  Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.

Authors:  David Durantel; Sandra Carrouée-Durantel; Norica Branza-Nichita; Raymond A Dwek; Nicole Zitzmann
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

4.  Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism.

Authors:  Susan J Baigent; Gang Zhang; Martin D Fray; Helen Flick-Smith; Stephen Goodbourn; John W McCauley
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

5.  Toll-like receptor responses to Peste des petits ruminants virus in goats and water buffalo.

Authors:  Sakthivel Dhanasekaran; Moanaro Biswas; Ambothi R Vignesh; R Ramya; Gopal Dhinakar Raj; Krishnaswamy G Tirumurugaan; Angamuthu Raja; Ranjit S Kataria; Satya Parida; Subbiah Elankumaran; Elankumaran Subbiah
Journal:  PLoS One       Date:  2014-11-04       Impact factor: 3.240

Review 6.  Camel viral diseases: Current diagnostic, therapeutic, and preventive strategies.

Authors:  Mahmoud Kandeel; Abdullah I A Al-Mubarak
Journal:  Front Vet Sci       Date:  2022-08-11
  6 in total

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