C Winkler1, S Dornfeld, R Schwarz, S Friedrich, M Baumann. 1. Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden.
Abstract
AIM: Retrospective assessment of the efficacy of radiation therapy for meningiomas with high risk for local recurrence. PATIENTS AND METHODS: Records of 67 patients with meningiomas treated from 1974 to 1995 at 2 centres were analyzed. Follow-up time ranged from 0.8 to 213 months (median: 61 months). Radiation therapy was given either after local failure or after biopsy or subtotal resection. The ratio between malignant (n = 20) and benign (n = 47) meningioma was 1:2.4. Median age of the patients was 55 years (7 to 77 years). Radiation treatment was given at 1.5 to 2 Gy per fraction to 36 to 79.5 Gy. Survival rates were calculated by the Kaplan-Meier method. Statistical comparisons were performed with the log-rank test and the Cox proportional hazards model. The Bonferroni method was used to correct for multiple comparisons. RESULTS: Five- and 10-year disease-free survival rates were 82% +/- 5% (standard error) and 70% +/- 9%. Local control rates at 5 and 10 years were 78% +/- 5% and 68% +/- 9%. In uni- and multivariate analysis histology, sex, total dose and center showed no significant influence on the results. Patients age was significant for local control (univariate p = 0.02; multivariate p = 0.03) and disease-free survival (univariate/multivariate p = 0.04). The postoperative tumor burden had a significant influence of disease-free survival (multivariate p = 0.04). After Bonferroni correction no significant influence was observed. We did not observe late side effects, especially brain necrosis. CONCLUSIONS: Despite of the negative selection of our patients we observed high survival- and local control rates after radiation therapy. This underscores the role of radiation therapy in the treatment of meningiomas with high risk of local failure.
AIM: Retrospective assessment of the efficacy of radiation therapy for meningiomas with high risk for local recurrence. PATIENTS AND METHODS: Records of 67 patients with meningiomas treated from 1974 to 1995 at 2 centres were analyzed. Follow-up time ranged from 0.8 to 213 months (median: 61 months). Radiation therapy was given either after local failure or after biopsy or subtotal resection. The ratio between malignant (n = 20) and benign (n = 47) meningioma was 1:2.4. Median age of the patients was 55 years (7 to 77 years). Radiation treatment was given at 1.5 to 2 Gy per fraction to 36 to 79.5 Gy. Survival rates were calculated by the Kaplan-Meier method. Statistical comparisons were performed with the log-rank test and the Cox proportional hazards model. The Bonferroni method was used to correct for multiple comparisons. RESULTS: Five- and 10-year disease-free survival rates were 82% +/- 5% (standard error) and 70% +/- 9%. Local control rates at 5 and 10 years were 78% +/- 5% and 68% +/- 9%. In uni- and multivariate analysis histology, sex, total dose and center showed no significant influence on the results. Patients age was significant for local control (univariate p = 0.02; multivariate p = 0.03) and disease-free survival (univariate/multivariate p = 0.04). The postoperative tumor burden had a significant influence of disease-free survival (multivariate p = 0.04). After Bonferroni correction no significant influence was observed. We did not observe late side effects, especially brain necrosis. CONCLUSIONS: Despite of the negative selection of our patients we observed high survival- and local control rates after radiation therapy. This underscores the role of radiation therapy in the treatment of meningiomas with high risk of local failure.
Authors: W Hoffmann; H Mühleisen; C F Hess; R D Kortmann; B Schmidt; E H Grote; M Bamberg Journal: Acta Neurochir (Wien) Date: 1995 Impact factor: 2.216
Authors: G L Jiang; S L Tucker; R Guttenberger; L J Peters; W H Morrison; A S Garden; C S Ha; K K Ang Journal: Radiother Oncol Date: 1994-01 Impact factor: 6.280
Authors: I Compter; K Zaugg; R M A Houben; J T A Dings; G Bosmans; C Buescher; M M H M E Anten; B G Baumert Journal: Strahlenther Onkol Date: 2012-09-09 Impact factor: 3.621
Authors: Leland Rogers; Igor Barani; Marc Chamberlain; Thomas J Kaley; Michael McDermott; Jeffrey Raizer; David Schiff; Damien C Weber; Patrick Y Wen; Michael A Vogelbaum Journal: J Neurosurg Date: 2015-01 Impact factor: 5.115
Authors: Barbara M Hahn; Ulrich M H Schrell; Rolf Sauer; Rudolf Fahlbusch; Oliver Ganslandt; Gerhard G Grabenbauer Journal: J Neurooncol Date: 2005-09 Impact factor: 4.130
Authors: Albert Attia; Michael D Chan; Ryan T Mott; Greg B Russell; David Seif; J Daniel Bourland; Allan F Deguzman; Thomas L Ellis; Kevin P McMullen; Michael T Munley; Stephen B Tatter; Edward G Shaw Journal: J Neurooncol Date: 2012-02-23 Impact factor: 4.130
Authors: Taylor Anne Wilson; Lei Huang; Dinesh Ramanathan; Miguel Lopez-Gonzalez; Promod Pillai; Kenneth De Los Reyes; Muhammad Kumal; Warren Boling Journal: Front Oncol Date: 2020-11-20 Impact factor: 6.244