Literature DB >> 9878851

Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183.

J Lei1, A Jiang, D Pei.   

Abstract

We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32-kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.

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Year:  1998        PMID： 9878851     DOI： 10.1016/s0167-4781(98)00240-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


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