Literature DB >> 9876869

Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.

H Kinouchi1, H Kamii, S Mikawa, C J Epstein, T Yoshimoto, P H Chan.   

Abstract

1. Nitric oxide radicals (NO) play an important role in the pathophysiology of focal cerebral ischemia. 2. Vascular NO can reduce ischemic brain injury by increasing CBF, whereas neuronal NO may mediate neurotoxicity following brain ischemia, mainly by its reaction with superoxide to generate peroxynitrite. 3. These findings could contribute to a strategy for the treatment of cerebral ischemia.

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Year:  1998        PMID： 9876869     DOI： 10.1023/a:1020677701368

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  30 in total

1.  Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia.

Authors:  P H Chan; H Kinouchi; C J Epstein; E Carlson; S F Chen; S Imaizumi; G Y Yang
Journal:  Prog Brain Res       Date:  1993       Impact factor: 2.453

2.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Authors:  J S Beckman; T W Beckman; J Chen; P A Marshall; B A Freeman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

3.  Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia.

Authors:  P H Chan; H Kamii; G Yang; J Gafni; C J Epstein; E Carlson; L Reola
Journal:  Neuroreport       Date:  1993-12-13       Impact factor: 1.837

4.  Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.

Authors:  V L Dawson; T M Dawson; D A Bartley; G R Uhl; S H Snyder
Journal:  J Neurosci       Date:  1993-06       Impact factor: 6.167

5.  Effects of nitric oxide synthase inhibition on cerebral blood flow following bilateral carotid artery occlusion and recirculation in the rat.

Authors:  R Prado; B D Watson; P Wester
Journal:  J Cereb Blood Flow Metab       Date:  1993-07       Impact factor: 6.200

6.  The reaction of no with superoxide.

Authors:  R E Huie; S Padmaja
Journal:  Free Radic Res Commun       Date:  1993

7.  ALS, SOD and peroxynitrite.

Authors:  J S Beckman; M Carson; C D Smith; W H Koppenol
Journal:  Nature       Date:  1993-08-12       Impact factor: 49.962

8.  Inhibition of nitric oxide synthesis impairs autoregulation of local cerebral blood flow in the rat.

Authors:  K Tanaka; Y Fukuuchi; S Gomi; B Mihara; T Shirai; S Nogawa; H Nozaki; E Nagata
Journal:  Neuroreport       Date:  1993-03       Impact factor: 1.837

9.  Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase.

Authors:  P H Chan; G Y Yang; S F Chen; E Carlson; C J Epstein
Journal:  Ann Neurol       Date:  1991-05       Impact factor: 10.422

10.  Blockade of nitric oxide formation by N omega-nitro-L-arginine mitigates ischemic brain edema and subsequent cerebral infarction in rats.

Authors:  T Nagafuji; T Matsui; T Koide; T Asano
Journal:  Neurosci Lett       Date:  1992-12-07       Impact factor: 3.046
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  3 in total

1.  The Long-Term Impairment in Redox Homeostasis Observed in the Hippocampus of Rats Subjected to Global Perinatal Asphyxia (PA) Implies Changes in Glutathione-Dependent Antioxidant Enzymes and TIGAR-Dependent Shift Towards the Pentose Phosphate Pathways: Effect of Nicotinamide.

Authors:  C Lespay-Rebolledo; A Tapia-Bustos; D Bustamante; P Morales; M Herrera-Marschitz
Journal:  Neurotox Res       Date:  2019-06-11       Impact factor: 3.911

Review 2.  AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke.

Authors:  Mangala M Soundarapandian; Wei Hong Tu; Peter L Peng; Antonis S Zervos; YouMing Lu
Journal:  Mol Neurobiol       Date:  2005-10       Impact factor: 5.682

3.  Baicalin's Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo.

Authors:  Fafeng Cheng; Yi Lu; Xianggen Zhong; Wenting Song; Xueqian Wang; Xiaoguang Sun; Jianguo Qin; Shaoying Guo; Qingguo Wang
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-25       Impact factor: 2.629
  3 in total

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