Literature DB >> 9876240

Vasoactive intestinal peptide in thymus: synthesis, receptors and biological actions.

M Delgado1, C Martinez, J Leceta, R P Gomariz.   

Abstract

Evidence summarized in this report indicates that thymocytes produce and secrete VIP. Moreover, different stimuli such as Con A, LPS and anti-TCR antibody induce a significant increase in VIP production by thymocytes. In addition, proinflammatory cytokines such as IL-1, IL-6 and TNF-alpha, but not IL-2, stimulate in a similar time-dependent manner VIP production by lymphocytes. We also describe the expression of VIP1 receptor and VIP2 receptor mRNA in murine thymocytes. Thus, VIP released in thymus microenvironment may modulate immune functions through direct binding to VIP receptors on thymocytes. Our functional data support that VIP through the interaction with their specific receptors affect three important aspects of thymocytes function: cytokine production, mobility and apoptosis.

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Year:  1999        PMID： 9876240     DOI： 10.1159/000026369

Source DB:  PubMed          Journal:  Neuroimmunomodulation        ISSN： 1021-7401            Impact factor:   2.492


  7 in total

1.  Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice.

Authors:  John P Vu; Mulugeta Million; Muriel Larauche; Leon Luong; Joshua Norris; James A Waschek; Charalabos Pothoulakis; Joseph R Pisegna; Patrizia M Germano
Journal:  J Mol Neurosci       Date:  2014-01-07       Impact factor: 3.444

2.  Radical reversal of vasoactive intestinal peptide (VIP) receptors during early lymphopoiesis.

Authors:  Emilie E Vomhof-DeKrey; Ashley R Sandy; Jarrett J Failing; Rebecca J Hermann; Scott A Hoselton; Jane M Schuh; Abby J Weldon; Kimberly J Payne; Glenn P Dorsam
Journal:  Peptides       Date:  2011-08-22       Impact factor: 3.750

3.  Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC(2) receptor for vasoactive intestinal peptide.

Authors:  E J Goetzl; J K Voice; S Shen; G Dorsam; Y Kong; K M West; C F Morrison; A J Harmar
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

4.  The absence of the VPAC(2) receptor does not protect mice from Aspergillus induced allergic asthma.

Authors:  A E Samarasinghe; S A Hoselton; J M Schuh
Journal:  Peptides       Date:  2010-03-11       Impact factor: 3.750

5.  Vasoactive intestinal peptide receptor 1 is downregulated during expansion of antigen-specific CD8 T cells following primary and secondary Listeria monocytogenes infections.

Authors:  Emilie E Vomhof-DeKrey; Jodie S Haring; Glenn P Dorsam
Journal:  J Neuroimmunol       Date:  2011-03-10       Impact factor: 3.478

Review 6.  Nerve-derived transmitters including peptides influence cutaneous immunology.

Authors:  Elizabeth N Madva; Richard D Granstein
Journal:  Brain Behav Immun       Date:  2013-03-18       Impact factor: 7.217

7.  The Gut's Little Brain in Control of Intestinal Immunity.

Authors:  Wouter J de Jonge
Journal:  ISRN Gastroenterol       Date:  2013-04-04
  7 in total

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