| Literature DB >> 9875517 |
S H Chae1, P S Kim, J Y Cho, J S Park, J H Lee, E S Yoo, K U Baik, J S Lee, M H Park.
Abstract
Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM).Entities:
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Year: 1998 PMID： 9875517 DOI： 10.1007/bf03216755
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946