BACKGROUND: Haemostasis plays a major part in the process initiating a myocardial infarction. The impact of haemostatic variables on long term prognosis is unknown. OBJECTIVE: To evaluate von Willebrand factor (vWF), tissue plasminogen activator antigen (t-PA) and its activity before and after venous occlusion, plasminogen activator inhibitor (PAI-1), dehydroepian-drosterone sulphate (DHEAS), and established clinical risk factors as long term predictors for reinfarction and mortality. PATIENTS: 123 consecutive survivors of myocardial infarction followed up for 10 years. DESIGN: Study entry took place between 1982 and 1983. Fifty seven patients died (54 of cardiovascular disease) during the mean observation time of 10 years. RESULTS: Cox's univariate regression analysis showed that cardiovascular mortality was significantly associated with age, hypertension, previous history of angina pectoris, DHEAS, mass concentration of t-PA, and vWF. These associations were significant for vWF and mass concentration of t-PA after adjusting for age and hypertension. CONCLUSIONS: A low concentration of DHEAS and high levels of the endothelially derived haemostatic variables vWF and mass concentration of t-PA are predictors of cardiovascular mortality in survivors of myocardial infarction. This association is independent of established clinical risk factors for mass concentration of t-PA and vWF.
BACKGROUND: Haemostasis plays a major part in the process initiating a myocardial infarction. The impact of haemostatic variables on long term prognosis is unknown. OBJECTIVE: To evaluate von Willebrand factor (vWF), tissue plasminogen activator antigen (t-PA) and its activity before and after venous occlusion, plasminogen activator inhibitor (PAI-1), dehydroepian-drosterone sulphate (DHEAS), and established clinical risk factors as long term predictors for reinfarction and mortality. PATIENTS: 123 consecutive survivors of myocardial infarction followed up for 10 years. DESIGN: Study entry took place between 1982 and 1983. Fifty seven patients died (54 of cardiovascular disease) during the mean observation time of 10 years. RESULTS: Cox's univariate regression analysis showed that cardiovascular mortality was significantly associated with age, hypertension, previous history of angina pectoris, DHEAS, mass concentration of t-PA, and vWF. These associations were significant for vWF and mass concentration of t-PA after adjusting for age and hypertension. CONCLUSIONS: A low concentration of DHEAS and high levels of the endothelially derived haemostatic variables vWF and mass concentration of t-PA are predictors of cardiovascular mortality in survivors of myocardial infarction. This association is independent of established clinical risk factors for mass concentration of t-PA and vWF.
Authors: T W Meade; S Mellows; M Brozovic; G J Miller; R R Chakrabarti; W R North; A P Haines; Y Stirling; J D Imeson; S G Thompson Journal: Lancet Date: 1986-09-06 Impact factor: 79.321
Authors: A P Haines; D Howarth; W R North; E Goldenberg; Y Stirling; T W Meade; E B Raftery; M W Millar Craig Journal: Thromb Haemost Date: 1983-12-30 Impact factor: 5.249
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Authors: Guangju Zhai; Alexander Teumer; Lisette Stolk; John R B Perry; Liesbeth Vandenput; Andrea D Coviello; Annemarie Koster; Jordana T Bell; Shalender Bhasin; Joel Eriksson; Anna Eriksson; Florian Ernst; Luigi Ferrucci; Timothy M Frayling; Daniel Glass; Elin Grundberg; Robin Haring; Asa K Hedman; Albert Hofman; Douglas P Kiel; Heyo K Kroemer; Yongmei Liu; Kathryn L Lunetta; Marcello Maggio; Mattias Lorentzon; Massimo Mangino; David Melzer; Iva Miljkovic; Alexandra Nica; Brenda W J H Penninx; Ramachandran S Vasan; Fernando Rivadeneira; Kerrin S Small; Nicole Soranzo; André G Uitterlinden; Henry Völzke; Scott G Wilson; Li Xi; Wei Vivian Zhuang; Tamara B Harris; Joanne M Murabito; Claes Ohlsson; Anna Murray; Frank H de Jong; Tim D Spector; Henri Wallaschofski Journal: PLoS Genet Date: 2011-04-14 Impact factor: 5.917
Authors: Richard G Jung; Pouya Motazedian; F Daniel Ramirez; Trevor Simard; Pietro Di Santo; Sarah Visintini; Mohammad Ali Faraz; Alisha Labinaz; Young Jung; Benjamin Hibbert Journal: Thromb J Date: 2018-06-05