AIM: To determine whether measurement of serum troponin T concentration after first acute myocardial infarction can be used to identify patients with a left ventricular ejection fraction of < 40%, who have an adverse prognosis. METHODS: Troponin T concentration was measured, and coronary and left ventriculography performed in 50 consecutive patients with acute myocardial infarction. Angiographic left ventricular ejection fraction was compared with serum troponin T concentration. Patients with previous myocardial infarction were excluded. RESULTS: There was a strong negative correlation between left ventricular ejection fraction and troponin T concentration. Spearman's rank correlation coefficient (corrected for ties) was -0.72 (95% confidence intervals (CI) -0.55 to -0.83; p < 0.0001). Analysis by receiver operator characteristic curve produced an area under the curve of 0.9773 (95% CI 0.9409 to 1.0136). A troponin T concentration of > 2.8 micrograms/l predicted a left ventricular ejection fraction of < 40% with a sensitivity of 100% (CI 84.6 to 100.0) and specificity of 92.9% (CI 76.5 to 99.1). Exclusion of patients who did not receive thrombolytic treatment did not significantly affect the results. CONCLUSION: Serum troponin T concentration measured 12-48 hours after admission for first myocardial infarction is a reliable, simple, quick, inexpensive, non-invasive method for identifying patients with a left ventricular ejection fraction of < 40% for whom there is a poor prognosis.
AIM: To determine whether measurement of serum troponin T concentration after first acute myocardial infarction can be used to identify patients with a left ventricular ejection fraction of < 40%, who have an adverse prognosis. METHODS: Troponin T concentration was measured, and coronary and left ventriculography performed in 50 consecutive patients with acute myocardial infarction. Angiographic left ventricular ejection fraction was compared with serum troponin T concentration. Patients with previous myocardial infarction were excluded. RESULTS: There was a strong negative correlation between left ventricular ejection fraction and troponin T concentration. Spearman's rank correlation coefficient (corrected for ties) was -0.72 (95% confidence intervals (CI) -0.55 to -0.83; p < 0.0001). Analysis by receiver operator characteristic curve produced an area under the curve of 0.9773 (95% CI 0.9409 to 1.0136). A troponin T concentration of > 2.8 micrograms/l predicted a left ventricular ejection fraction of < 40% with a sensitivity of 100% (CI 84.6 to 100.0) and specificity of 92.9% (CI 76.5 to 99.1). Exclusion of patients who did not receive thrombolytic treatment did not significantly affect the results. CONCLUSION: Serum troponin T concentration measured 12-48 hours after admission for first myocardial infarction is a reliable, simple, quick, inexpensive, non-invasive method for identifying patients with a left ventricular ejection fraction of < 40% for whom there is a poor prognosis.
Authors: M A Pfeffer; E Braunwald; L A Moyé; L Basta; E J Brown; T E Cuddy; B R Davis; E M Geltman; S Goldman; G C Flaker Journal: N Engl J Med Date: 1992-09-03 Impact factor: 91.245
Authors: D B Hackel; K A Reimer; R E Ideker; E M Mikat; T D Hartwell; C B Parker; E B Braunwald; M Buja; H K Gold; A S Jaffe Journal: Circulation Date: 1984-11 Impact factor: 29.690
Authors: H A Katus; A Remppis; F J Neumann; T Scheffold; K W Diederich; G Vinar; A Noe; G Matern; W Kuebler Journal: Circulation Date: 1991-03 Impact factor: 29.690
Authors: LeRoy Elazar Rabbani; Carol Waksmonski; Sohah N Iqbal; Jennifer Stant; Robert Sciacca; Mark Apfelbaum; Osman R Sayan; James Giglio; Shunichi Homma Journal: J Thromb Thrombolysis Date: 2007-06-12 Impact factor: 2.300
Authors: Antonio Haddad Tapias Filho; Gustavo Bernardes de Figueiredo Oliveira; João Italo Dias França; Rui Fernando Ramos Journal: Arq Bras Cardiol Date: 2022-05-09 Impact factor: 2.667
Authors: Henry Anselmo Mayala; Magesa Mafuru; Abdalah Mkangala; Mark Mayala; Pedro Pallangyo; Dickson Minja; Mohamed Janabi; Wang Zhao-Hui Journal: BMC Res Notes Date: 2020-03-16