Literature DB >> 9873739

Inhibition of topoisomerase I by naphthoquinone derivatives.

Z F Plyta1, T Li, V P Papageorgiou, A S Mellidis, A N Assimopoulou, E N Pitsinos, E A Couladouros.   

Abstract

Alkannin and shikonin are naturally occurring naphthoquinones. We have tested several derivatives of the title compounds and we have found that naphthoquinones bearing at least one phenolic hydroxyl group are potent inhibitors of topoisomerase I. The ability of the tested compounds to complex Zn++ parallels with a few exceptions their topoisomerase I inhibition properties while their intercalation and redox properties do not.

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Year:  1998        PMID： 9873739     DOI： 10.1016/s0960-894x(98)00600-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells.

Authors:  Nguyen Huu Tung; Guang-Jian Du; Chong-Zhi Wang; Chun-Su Yuan; Yukihiro Shoyama
Journal:  Phytother Res       Date:  2012-04-04       Impact factor: 5.878

2.  Shikonin changes the lipopolysaccharide-induced expression of inflammation-related genes in macrophages.

Authors:  Lucia Satiko Yoshida; Tomohito Kakegawa; Yasukatsu Yuda; Hiromi Takano-Ohmuro
Journal:  J Nat Med       Date:  2017-07-11       Impact factor: 2.343

3.  Theoretical investigation of the radical scavenging activity of shikonin and acylshikonin derivatives.

Authors:  Ruifa Jin; Yin Bai
Journal:  J Mol Model       Date:  2011-07-15       Impact factor: 1.810

4.  The study of naphthoquinones and their complexes with DNA by using Raman spectroscopy and surface enhanced Raman spectroscopy: new insight into interactions of DNA with plant secondary metabolites.

Authors:  Veronika Vaverkova; Oldrich Vrana; Vojtech Adam; Tomas Pekarek; Josef Jampilek; Petr Babula
Journal:  Biomed Res Int       Date:  2014-06-22       Impact factor: 3.411

5.  Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.

Authors:  Qiaoli Zhao; Andreana N Assimopoulou; Sabine M Klauck; Harilaos Damianakos; Ioanna Chinou; Nadine Kretschmer; José-Luis Rios; Vassilios P Papageorgiou; Rudolf Bauer; Thomas Efferth
Journal:  Oncotarget       Date:  2015-11-17

6.  Anticancer agent shikonin is an incompetent inducer of cancer drug resistance.

Authors:  Hao Wu; Jiansheng Xie; Qiangrong Pan; Beibei Wang; Danqing Hu; Xun Hu
Journal:  PLoS One       Date:  2013-01-03       Impact factor: 3.240

7.  Apoptosis induced by β,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in human breast carcinoma MCF-7 cells.

Authors:  Yao Xiong; Xiu-Ying Ma; Ziran Zhang; Zhen-Jun Shao; Yuan-Yuan Zhang; Li-Ming Zhou
Journal:  Oncol Lett       Date:  2013-10-10       Impact factor: 2.967

Review 8.  Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants.

Authors:  Joshua R Widhalm; David Rhodes
Journal:  Hortic Res       Date:  2016-09-21       Impact factor: 6.793

9.  Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells.

Authors:  Christin Durchschein; Antje Hufner; Beate Rinner; Alexander Stallinger; Alexander Deutsch; Birgit Lohberger; Rudolf Bauer; Nadine Kretschmer
Journal:  Molecules       Date:  2018-10-30       Impact factor: 4.411

10.  Synthesis, leishmanicidal activity and theoretical evaluations of a series of substituted bis-2-hydroxy-1,4-naphthoquinones.

Authors:  Morgana V de Araújo; Patricia S O de Souza; Aline C de Queiroz; Carolina B B da Matta; Anderson Brandão Leite; Amanda Evelyn da Silva; José A A de França; Tania M S Silva; Celso A Camara; Magna S Alexandre-Moreira
Journal:  Molecules       Date:  2014-09-22       Impact factor: 4.411
  10 in total

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