Literature DB >> 9873736

Novel B-ring modified combretastatin analogues: syntheses and antineoplastic activity.

T Hatanaka1, K Fujita, K Ohsumi, R Nakagawa, Y Fukuda, Y Nihei, Y Suga, Y Akiyama, T Tsuji.   

Abstract

A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.

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Year:  1998        PMID： 9873736     DOI： 10.1016/s0960-894x(98)00622-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

1.  Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; Carlota Lopez Cara; Maria Dora Carrion; Andrea Brancale; Ernest Hamel; Longchuan Chen; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

2.  Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Carlota Lopez-Cara; Olga Cruz-Lopez; Maria Dora Carrion; Maria Kimatrai Salvador; Jaime Bermejo; Sara Estévez; Francisco Estévez; Jan Balzarini; Andrea Brancale; Antonio Ricci; Longchuan Chen; Jae Gwan Kim; Ernest Hamel
Journal:  ChemMedChem       Date:  2011-08-01       Impact factor: 3.466

3.  Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors.

Authors:  Yang Ping Quan; Li Ping Cheng; Tian Chi Wang; Wan Pang; Fan Hong Wu; Jin Wen Huang
Journal:  Medchemcomm       Date:  2017-12-06       Impact factor: 3.597

4.  Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Andrea Brancale; Antonio Ricci; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-06-27       Impact factor: 7.446

5.  Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Carlota Lopez Cara; Ernest Hamel; Giuseppe Basso; Roberta Bortolozzi; Giampietro Viola
Journal:  Eur J Med Chem       Date:  2010-10-08       Impact factor: 6.514

6.  Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Delia Preti; Mojgan Aghazadeh Tabrizi; Marcella Bassetto; Andrea Brancale; Ernest Hamel; Ignazio Castagliuolo; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2013-03-18       Impact factor: 7.446

Review 7.  The biology of the combretastatins as tumour vascular targeting agents.

Authors:  Gillian M Tozer; Chryso Kanthou; Charles S Parkins; Sally A Hill
Journal:  Int J Exp Pathol       Date:  2002-02       Impact factor: 1.925

8.  Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; M Encarnacion Camacho; Delia Preti; Mojgan Aghazadeh Tabrizi; Marcella Bassetto; Andrea Brancale; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  Bioorg Med Chem       Date:  2012-10-12       Impact factor: 3.641

9.  Design and synthesis of 3,5-disubstituted boron-containing 1,2,4-oxadiazoles as potential combretastatin A-4 (CA-4) analogs.

Authors:  Bhaskar C Das; Xiang-Ying Tang; Patrick Rogler; Todd Evans
Journal:  Tetrahedron Lett       Date:  2012-08-01       Impact factor: 2.415

10.  A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

Authors:  K Hori; S Saito; K Kubota
Journal:  Br J Cancer       Date:  2002-05-20       Impact factor: 7.640
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