Literature DB >> 9873731

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin.

G M Dubowchik1, R A Firestone.   

Abstract

A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.

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Year:  1998        PMID： 9873731     DOI： 10.1016/s0960-894x(98)00609-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  39 in total

1.  Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation.

Authors:  Handan Acar; Ravand Samaeekia; Mathew R Schnorenberg; Dibyendu K Sasmal; Jun Huang; Matthew V Tirrell; James L LaBelle
Journal:  Bioconjug Chem       Date:  2017-08-24       Impact factor: 4.774

2.  A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action.

Authors:  Alexander Komin; Maxim I Bogorad; Ran Lin; Honggang Cui; Peter C Searson; Kalina Hristova
Journal:  J Control Release       Date:  2020-05-28       Impact factor: 9.776

Review 3.  Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.

Authors:  Satish K Singh; Donna L Luisi; Roger H Pak
Journal:  Pharm Res       Date:  2015-05-19       Impact factor: 4.200

4.  Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.

Authors:  Maria J Matos; Claudio D Navo; Tuuli Hakala; Xhenti Ferhati; Ana Guerreiro; David Hartmann; Barbara Bernardim; Kadi L Saar; Ismael Compañón; Francisco Corzana; Tuomas P J Knowles; Gonzalo Jiménez-Osés; Gonçalo J L Bernardes
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-09       Impact factor: 15.336

5.  Molecular design and synthesis of self-assembling camptothecin drug amphiphiles.

Authors:  Andrew G Cheetham; Yi-An Lin; Ran Lin; Honggang Cui
Journal:  Acta Pharmacol Sin       Date:  2017-03-06       Impact factor: 6.150

6.  Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release.

Authors:  David S H Chu; Russell N Johnson; Suzie H Pun
Journal:  J Control Release       Date:  2011-10-20       Impact factor: 9.776

7.  Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.

Authors:  Leanna R Staben; Stefan G Koenig; Sophie M Lehar; Richard Vandlen; Donglu Zhang; Josefa Chuh; Shang-Fan Yu; Carl Ng; Jun Guo; Yanzhou Liu; Aimee Fourie-O'Donohue; MaryAnn Go; Xin Linghu; Nathaniel L Segraves; Tao Wang; Jinhua Chen; BinQing Wei; Gail D Lewis Phillips; Keyang Xu; Katherine R Kozak; Sanjeev Mariathasan; John A Flygare; Thomas H Pillow
Journal:  Nat Chem       Date:  2016-10-17       Impact factor: 24.427

8.  Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization.

Authors:  Barney Yoo; Kai Ma; Li Zhang; Andrew Burns; Sonia Sequeira; Ingo Mellinghoff; Cameron Brennan; Ulrich Wiesner; Michelle S Bradbury
Journal:  Bioorg Med Chem       Date:  2015-10-11       Impact factor: 3.641

9.  Enzyme-Cleavable Polymeric Micelles for the Intracellular Delivery of Proapoptotic Peptides.

Authors:  Hanna B Kern; Selvi Srinivasan; Anthony J Convertine; David Hockenbery; Oliver W Press; Patrick S Stayton
Journal:  Mol Pharm       Date:  2017-03-30       Impact factor: 4.939

10.  Optimization of an albumin-binding prodrug of Doxorubicin that is cleaved by prostate-specific antigen.

Authors:  Bakheet Elsadek; Ralph Graeser; André Warnecke; Clemens Unger; Tahia Saleem; Nagla El-Melegy; Hafez Madkor; Felix Kratz
Journal:  ACS Med Chem Lett       Date:  2010-05-26       Impact factor: 4.345
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