| Literature DB >> 9873730 |
J R Henry1, K C Rupert, J H Dodd, I J Turchi, S A Wadsworth, D E Cavender, P H Schafer, J J Siekierka.
Abstract
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.Entities:
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Year: 1998 PMID： 9873730 DOI： 10.1016/s0960-894x(98)00589-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823