Literature DB >> 9873727

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.

W Lew1, H Wu, D B Mendel, P A Escarpe, X Chen, W G Laver, B J Graves, C U Kim.   

Abstract

The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.

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Year:  1998        PMID: 9873727     DOI: 10.1016/s0960-894x(98)00587-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  6 in total

1.  Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models.

Authors:  Wenwen Lian; Jiansong Fang; Chao Li; Xiaocong Pang; Ai-Lin Liu; Guan-Hua Du
Journal:  Mol Divers       Date:  2015-12-21       Impact factor: 2.943

2.  Implications of protein conformations to modifying novel inhibitor Oseltamivir for 2009 H1N1 influenza A virus by simulation and docking studies.

Authors:  Sudha Singh; Anvita Gupta Malhotra; Mohit Jha; Khushhali Menaria Pandey
Journal:  Virusdisease       Date:  2018-09-01

3.  Consensus QSAR model for identifying novel H5N1 inhibitors.

Authors:  Nitin Sharma; Chun Wei Yap
Journal:  Mol Divers       Date:  2012-07-21       Impact factor: 2.943

4.  Predicting dual-targeting anti-influenza agents using multi-models.

Authors:  Yu Wang; Hu Ge; Yali Li; Yufang Xie; Yingyan He; Mengyan Xu; Qiong Gu; Jun Xu
Journal:  Mol Divers       Date:  2014-10-02       Impact factor: 2.943

5.  QSAR analyses on avian influenza virus neuraminidase inhibitors using CoMFA, CoMSIA, and HQSAR.

Authors:  Mingyue Zheng; Kunqian Yu; Hong Liu; Xiaomin Luo; Kaixian Chen; Weiliang Zhu; Hualiang Jiang
Journal:  J Comput Aided Mol Des       Date:  2006-11-11       Impact factor: 3.686

6.  Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains.

Authors:  Kai-Cheng Hsu; Hui-Chen Hung; Wei-Chun HuangFu; Tzu-Ying Sung; Tony Eight Lin; Ming-Yu Fang; I-Jung Chen; Nikhil Pathak; John T-A Hsu; Jinn-Moon Yang
Journal:  Sci Rep       Date:  2017-09-26       Impact factor: 4.379

  6 in total

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