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Literature DB >> 9873716

Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects.

Abstract

Mixed-backbone oligonucleotides containing alternative phosphorothioate and phosphodiester linkages in the 2'-O-methylribonucleosides segment show increased affinity with complementary targets, increased stability towards nucleases in vitro and in vivo, and reduced phosphorothioate-related prolongation of partial thromboplastin time compared to phosphorothioate oligodeoxynucleotides, thereby providing antisense agents with reduced side effects.

Entities: Chemical

Mesh：

Substances：

Year: 1998 PMID： 9873716 DOI： 10.1016/s0960-894x(98)00591-5

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

9 in total

1. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.

Authors: C Wahlestedt; P Salmi; L Good; J Kela; T Johnsson; T Hökfelt; C Broberger; F Porreca; J Lai; K Ren; M Ossipov; A Koshkin; N Jakobsen; J Skouv; H Oerum; M H Jacobsen; J Wengel
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

2. MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.

Authors: Angélique Gougelet; Sabine Colnot
Journal: World J Gastroenterol Date: 2013-01-28 Impact factor: 5.742

3. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death.

Authors: B Herbert; A E Pitts; S I Baker; S E Hamilton; W E Wright; J W Shay; D R Corey
Journal: Proc Natl Acad Sci U S A Date: 1999-12-07 Impact factor: 11.205

4. Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids.

Authors: A Y Denisov; A M Noronha; C J Wilds; J F Trempe; R T Pon; K Gehring; M J Damha
Journal: Nucleic Acids Res Date: 2001-11-01 Impact factor: 16.971

Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects.

1. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids.

2. MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.

3. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death.

4. Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids.

5. Molecular and cellular barriers limiting the effectiveness of antisense oligonucleotides.

6. Introduction and History of the Chemistry of Nucleic Acids Therapeutics.

Review 7. Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic.

8. Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics.

Review 9. The Evolution of Antisense Oligonucleotide Chemistry-A Personal Journey.