Literature DB >> 9873703

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.

C D Carroll1, T O Johnson, S Tao, G Lauri, M Orlowski, I Y Gluzman, D E Goldberg, R E Dolle.   

Abstract

A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1, P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.

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Year:  1998        PMID： 9873703     DOI： 10.1016/s0960-894x(98)00554-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries.

Authors:  T F Herpin; G C Morton; A K Dunn; C Fillon; P R Menard; S Y Tang; J M Salvino; R F Labaudinière
Journal:  Mol Divers       Date:  1998       Impact factor: 2.943

2.  Computational analysis of aspartic protease plasmepsin II complexed with EH58 inhibitor: a QM/MM MD study.

Authors:  Natália de Farias Silva; Jerônimo Lameira; Cláudio Nahum Alves
Journal:  J Mol Model       Date:  2011-01-25       Impact factor: 1.810

3.  New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins.

Authors:  S Jiang; S T Prigge; L Wei; T H Hudson; L Gerena; J B Dame; D E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

4.  Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors.

Authors:  Nidhi Mishra; Anand K Agrahari; Priyanka Bose; Sumit K Singh; Anoop S Singh; Vinod K Tiwari
Journal:  Sci Rep       Date:  2020-02-27       Impact factor: 4.379
  4 in total

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