Literature DB >> 9873694

Syntheses and antitumor activity of cis-restricted combretastatins: 5-membered heterocyclic analogues.

K Ohsumi1, T Hatanaka, K Fujita, R Nakagawa, Y Fukuda, Y Nihei, Y Suga, Y Morinaga, Y Akiyama, T Tsuji.   

Abstract

A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds 16 and 35 showed marked tumor growth suppression in the colon 26 murine tumor model.

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Year:  1998        PMID： 9873694     DOI： 10.1016/s0960-894x(98)00579-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  29 in total

1.  Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Delia Preti; Mojgan Aghazadeh Tabrizi; Andrea Brancale; Xian-Hua Fu; Jun Li; Su-Zhan Zhang; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-12-21       Impact factor: 7.446

2.  Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; Carlota Lopez Cara; Maria Dora Carrion; Andrea Brancale; Ernest Hamel; Longchuan Chen; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

3.  L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide.

Authors:  Narsimha Reddy Penthala; Nikhil Reddy Madadi; Venumadhav Janganati; Peter A Crooks
Journal:  Tetrahedron Lett       Date:  2014-10-01       Impact factor: 2.415

4.  Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues.

Authors:  Ganesh S Jedhe; Debasish Paul; Rajesh G Gonnade; Manas K Santra; Ernest Hamel; Tam Luong Nguyen; Gangadhar J Sanjayan
Journal:  Bioorg Med Chem Lett       Date:  2013-06-12       Impact factor: 2.823

Review 5.  An overview of tubulin inhibitors that interact with the colchicine binding site.

Authors:  Yan Lu; Jianjun Chen; Min Xiao; Wei Li; Duane D Miller
Journal:  Pharm Res       Date:  2012-07-20       Impact factor: 4.200

6.  Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Filippo Prencipe; Valerio Bertolasi; Michela Cancellieri; Andrea Brancale; Ernest Hamel; Ignazio Castagliuolo; Francesca Consolaro; Elena Porcù; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2014-07-28       Impact factor: 7.446

7.  Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Andrea Brancale; Antonio Ricci; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-06-27       Impact factor: 7.446

8.  Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents.

Authors:  Narsimha Reddy Penthala; Leena Madhukuri; Shraddha Thakkar; Nikhil Reddy Madadi; Gauri Lamture; Robert L Eoff; Peter A Crooks
Journal:  Medchemcomm       Date:  2015-06-30       Impact factor: 3.597

9.  Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Po-Kai Huang; Hsu-Chin Chan; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Bioorg Med Chem       Date:  2013-06-26       Impact factor: 3.641

10.  A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

Authors:  K Hori; S Saito; K Kubota
Journal:  Br J Cancer       Date:  2002-05-20       Impact factor: 7.640
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