Literature DB >> 9873691

Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP.

D J Witter1, S J Famiglietti, J C Cambier, A L Castelhano.   

Abstract

Spirolactam-based Pro-Pro mimetics incorporated in the consensus sequence XPpXP, lead to effective nonpeptide ligands of SH3 domains.

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Year:  1998        PMID： 9873691     DOI： 10.1016/s0960-894x(98)00577-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Allosteric modulation of the dopamine D2 receptor by Pro-Leu-Gly-NH2 peptidomimetics constrained in either a polyproline II helix or a type II beta-turn conformation.

Authors:  Bhooma Raghavan; Kevin J Skoblenick; Swapna Bhagwanth; Niran Argintaru; Ram K Mishra; Rodney L Johnson
Journal:  J Med Chem       Date:  2009-04-09       Impact factor: 7.446

2.  Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.

Authors:  Wei Li; Alba Gigante; Maria-Jesus Perez-Perez; Hong Yue; Michio Hirano; Thomas M McIntyre; Roy L Silverstein
Journal:  Circ Res       Date:  2014-10-06       Impact factor: 17.367

3.  Development of peptidomimetic ligands of Pro-Leu-Gly-NH(2) as allosteric modulators of the dopamine D(2) receptor.

Authors:  Swapna Bhagwanth; Ram K Mishra; Rodney L Johnson
Journal:  Beilstein J Org Chem       Date:  2013-01-30       Impact factor: 2.883
  3 in total

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