Literature DB >> 9873680

Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.

M S Kuo1, M G Bock, R M Freidinger, M T Guidotti, E V Lis, J M Pawluczyk, D S Perlow, D J Pettibone, A G Quigley, D R Reiss, P D Williams, C J Woyden.   

Abstract

Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group.

Mesh：

Substances：

Year:  1998        PMID： 9873680     DOI： 10.1016/S0960-894X(98)00568-X

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  The 3D structure of the binding pocket of the human oxytocin receptor for benzoxazine antagonists, determined by molecular docking, scoring functions and 3D-QSAR methods.

Authors:  Balázs Jójárt; Tamás A Martinek; Arpád Márki
Journal:  J Comput Aided Mol Des       Date:  2005-05       Impact factor: 3.686

2.  Possible dynamic anchor points in a benzoxazinone derivative-human oxytocin receptor system--a molecular docking and dynamics calculation.

Authors:  Balázs Jójárt; Arpád Márki
Journal:  J Mol Model       Date:  2006-05-05       Impact factor: 1.810

3.  Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats.

Authors:  G Cristina Brailoiu; Elena Deliu; Andrei A Tica; Joseph E Rabinowitz; Douglas G Tilley; Khalid Benamar; Walter J Koch; Eugen Brailoiu
Journal:  J Neurochem       Date:  2013-07-19       Impact factor: 5.372

4.  Peripheral oxytocin injection modulates vomeronasal sensory activity and reduces pup-directed aggression in male mice.

Authors:  Thiago S Nakahara; Antonio P Camargo; Pedro H M Magalhães; Mateus A A Souza; Pedro G Ribeiro; Paulo H Martins-Netto; Vinicius M A Carvalho; Juliana José; Fabio Papes
Journal:  Sci Rep       Date:  2020-11-17       Impact factor: 4.379
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.