Literature DB >> 9873628

Design and synthesis of a pyridone-based phosphotyrosine mimetic.

J M Fu1, A L Castelhano.   

Abstract

A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of beta-iodoalanine with phosphonomethyl 4-pyridone triflate.

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Year:  1998        PMID： 9873628     DOI： 10.1016/s0960-894x(98)00503-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Design and synthesis of phosphotyrosine peptidomimetic prodrugs.

Authors:  Hugo Garrido-Hernandez; Kyung D Moon; Robert L Geahlen; Richard F Borch
Journal:  J Med Chem       Date:  2006-06-01       Impact factor: 7.446

2.  Improved convergence of binding affinities with free energy perturbation: application to nonpeptide ligands with pp60src SH2 domain.

Authors:  D J Price; W L Jorgensen
Journal:  J Comput Aided Mol Des       Date:  2001-08       Impact factor: 3.686

3.  The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.

Authors:  Richard Sims; Virginia Oberholzer Vandergon; Cindy S Malone
Journal:  Mol Biol Rep       Date:  2011-06-19       Impact factor: 2.316

4.  Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain.

Authors:  Etienne Tokonzaba; Daniel G S Capelluto; Tatiana G Kutateladze; Michael Overduin
Journal:  Chem Biol Drug Des       Date:  2006-03       Impact factor: 2.817
  4 in total

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