Literature DB >> 9873623

Synthesis and immunosuppressant activity of pyrazole carboxamides.

A X Wang1, Q Xie, B Lane, K W Mollison, G C Hsieh, K Marsh, M P Sheets, J R Luly, M J Coghlan.   

Abstract

A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 < 1 microM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.

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Year:  1998        PMID： 9873623     DOI： 10.1016/s0960-894x(98)00501-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.

Authors:  Timmy Mani; Degang Liu; Donghui Zhou; Liwei Li; William Eric Knabe; Fang Wang; Kyungsoo Oh; Samy O Meroueh
Journal:  ChemMedChem       Date:  2013-10-02       Impact factor: 3.466

2.  Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.

Authors:  Fang Wang; Jing Li; Anthony L Sinn; W Eric Knabe; May Khanna; Inha Jo; Jayne M Silver; Kyungsoo Oh; Liwei Li; George E Sandusky; George W Sledge; Harikrishna Nakshatri; David R Jones; Karen E Pollok; Samy O Meroueh
Journal:  J Med Chem       Date:  2011-10-04       Impact factor: 7.446
  2 in total

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