| Literature DB >> 9873621 |
R W Friesen1, C Brideau, C C Chan, S Charleson, D Deschênes, D Dubé, D Ethier, R Fortin, J Y Gauthier, Y Girard, R Gordon, G M Greig, D Riendeau, C Savoie, Z Wang, E Wong, D Visco, L J Xu, R N Young.
Abstract
A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2. Optimum COX-2 activity is observed by introduction of a substituent at C5 of the central pyridine. 5- Chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine 33 was identified as the optimum compound in this series.Entities:
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Year: 1998 PMID： 9873621 DOI： 10.1016/s0960-894x(98)00499-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823