Literature DB >> 9873614

Voltage-dependent ion channel formation by rigid rod-shaped polyols in planar lipid bilayers.

N Sakai1, C Ni, S M Bezrukov, S Matile.   

Abstract

In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rod-shaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.

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Year:  1998        PMID: 9873614     DOI: 10.1016/s0960-894x(98)00481-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  The C- and N-Terminal Residues of Synthetic Heptapeptide Ion Channels Influence Transport Efficacy Through Phospholipid Bilayers.

Authors:  Natasha Djedovič; Riccardo Ferdani; Egan Harder; Jolanta Pajewska; Robert Pajewski; Michelle E Weber; Paul H Schlesinger; George W Gokel
Journal:  New J Chem       Date:  2005-01-01       Impact factor: 3.591

2.  Planar-bilayer activities of linear oligoester bolaamphiphiles.

Authors:  Jonathan K W Chui; Thomas M Fyles; Horace Luong
Journal:  Beilstein J Org Chem       Date:  2011-11-22       Impact factor: 2.883

  2 in total

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