| Literature DB >> 9873592 |
J Milton1, M J Slater, A J Bird, D Spinks, G Scott, C E Price, S Downing, D V Green, S Madar, R Bethell, D K Stammers.
Abstract
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50S in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.Entities:
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Year: 1998 PMID： 9873592 DOI： 10.1016/s0960-894x(98)00214-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823