| Literature DB >> 9873565 |
Y J Hu1, P T Rajagopalan, D Pei.
Abstract
Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein maturation and is essential for bacterial survival. Its absence from eukaryotic organisms makes it an attractive target for designing novel antibacterial agents. Peptidyl H-phosphonates were synthesized and shown to be competitive inhibitors of the deformylase.Entities:
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Year: 1998 PMID： 9873565 DOI： 10.1016/s0960-894x(98)00443-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823