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Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.

D Ma¹, Z Ma, A P Kozikowski, S Pshenichkin, J T Wroblewski.

Abstract

Two analogues 2, 3 of (S)-alpha-methyl-3-carboxylphenylalanine 1 were synthesized to test their activity for metabotropic glutamate receptors (mGluRs). Both compounds 2 and 3 were inactive as antagonist for mGluRs, but 2 showed weak agonistic activity for GluR6 in contrast to that reported by Kemp and co-workers.

Entities: Chemical Gene

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Year: 1998 PMID： 9873559 DOI： 10.1016/s0960-894x(98)00409-0

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.

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