Literature DB >> 9873553

A photoactivated prodrug.

Y Wei1, Y Yan, D Pei, B Gong.   

Abstract

A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell growth.

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Year:  1998        PMID： 9873553     DOI： 10.1016/s0960-894x(98)00437-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.

Authors:  Christopher P Landowski; Xueqin Song; Philip L Lorenzi; John M Hilfinger; Gordon L Amidon
Journal:  Pharm Res       Date:  2005-08-24       Impact factor: 4.200

2.  A new class of 5-fluoro-2'-deoxyuridine prodrugs conjugated with a tumor-homing cyclic peptide CNGRC by ester linkers: synthesis, reactivity, and tumor-cell-selective cytotoxicity.

Authors:  Zhouen Zhang; Hiroshi Hatta; Kazuhito Tanabe; Sei-ichi Nishimoto
Journal:  Pharm Res       Date:  2005-03       Impact factor: 4.200

3.  Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.

Authors:  Balvinder S Vig; Philip J Lorenzi; Sachin Mittal; Christopher P Landowski; Ho-Chul Shin; Henry I Mosberg; John M Hilfinger; Gordon L Amidon
Journal:  Pharm Res       Date:  2003-09       Impact factor: 4.200

4.  Synthesis and in vitro evaluation of bile acid prodrugs of floxuridine to target the liver.

Authors:  Diana Vivian; James E Polli
Journal:  Int J Pharm       Date:  2014-09-16       Impact factor: 5.875

Review 5.  Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors.

Authors:  Takeo Ito; Kazuhito Tanabe; Hisatsugu Yamada; Hiroshi Hatta; Sei-ichi Nishimoto
Journal:  Molecules       Date:  2008-10-01       Impact factor: 4.411
  5 in total

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