Literature DB >> 9873546

Chemically-tagged Mitsunobu reagents for use in solution-phase chemical library synthesis.

G W Starkey1, J J Parlow, D L Flynn.   

Abstract

A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.

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Year:  1998        PMID： 9873546     DOI： 10.1016/s0960-894x(98)00431-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Monomer-on-monomer (MoM) Mitsunobu reaction: facile purification utilizing surface-initiated sequestration.

Authors:  Pradip K Maity; Alan Rolfe; Thiwanka B Samarakoon; Saqib Faisal; Ryan D Kurtz; Toby R Long; Alexander Schätz; Daniel L Flynn; Robert N Grass; Wendelin J Stark; Oliver Reiser; Paul R Hanson
Journal:  Org Lett       Date:  2010-12-01       Impact factor: 6.005

2.  Intramolecular monomer-on-monomer (MoM) Mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides.

Authors:  Pradip K Maity; Quirin M Kainz; Saqib Faisal; Alan Rolfe; Thiwanka B Samarakoon; Fatima Z Basha; Oliver Reiser; Paul R Hanson
Journal:  Chem Commun (Camb)       Date:  2011-10-26       Impact factor: 6.222

3.  High-loading polyglycerol supported reagents for Mitsunobu- and acylation-reactions and other useful polyglycerol derivatives.

Authors:  Sebastian Roller; Haixia Zhou; Rainer Haag
Journal:  Mol Divers       Date:  2005       Impact factor: 2.943
  3 in total

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