| Literature DB >> 9873534 |
C D Carroll1, H Patel, T O Johnson, T Guo, M Orlowski, Z M He, C L Cavallaro, J Guo, A Oksman, I Y Gluzman, J Connelly, D Chelsky, D E Goldberg, R E Dolle.
Abstract
An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease required for hemoglobin metabolism in the malaria parasite, led to the identification of potent and selective inhibitors as well as novel structure-activity relationships.Entities:
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Year: 1998 PMID： 9873534 DOI： 10.1016/s0960-894x(98)00419-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823