Literature DB >> 9873527

Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.

A Nefzi1, C Dooley, J M Ostresh, R A Houghten.   

Abstract

Modified dipeptides have been used successfully for the generation of a variety of small organic and heterocyclic combinatorial libraries, including linear urea, polyamine, hydantoin, thiohydantoin, cyclic urea, cyclic thiourea and bicyclic guanidine. The synthesis and screening results for a number of these libraries are described. The solid phase synthesis of heterocyclic compounds such as diazepine and thiomorpholinone are also described.

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Year:  1998        PMID: 9873527     DOI: 10.1016/s0960-894x(98)00412-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.

Authors:  Richard A Houghten; Colette T Dooley; Jon R Appel
Journal:  AAPS J       Date:  2006-05-26       Impact factor: 4.009

2.  Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade.

Authors:  Guillermo Gerona-Navarro; Rosario González-Muñiz; Asia Fernández-Carvajal; José M González-Ros; Antonio Ferrer-Montiel; Cristina Carreño; Fernando Albericio; Miriam Royo
Journal:  ACS Comb Sci       Date:  2011-07-08       Impact factor: 3.784

Review 3.  High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.

Authors:  Bainan Wu; Elisa Barile; Surya K De; Jun Wei; Angela Purves; Maurizio Pellecchia
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

4.  Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.

Authors:  Jay P McLaughlin; Ramanjaneyulu Rayala; Ashley J Bunnell; Mukund P Tantak; Shainnel O Eans; Khadija Nefzi; Michelle L Ganno; Colette T Dooley; Adel Nefzi
Journal:  Int J Mol Sci       Date:  2022-08-25       Impact factor: 6.208

5.  Ligand scaffold hopping combining 3D maximal substructure search and molecular similarity.

Authors:  Flavien Quintus; Olivier Sperandio; Julien Grynberg; Michel Petitjean; Pierre Tuffery
Journal:  BMC Bioinformatics       Date:  2009-08-11       Impact factor: 3.169

Review 6.  The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity.

Authors:  Martin Kalník; Peter Gabko; Maroš Bella; Miroslav Koóš
Journal:  Molecules       Date:  2021-06-30       Impact factor: 4.411

7.  Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF.

Authors:  Catherine Paradis-Bleau; Adrian Lloyd; François Sanschagrin; Tom Clarke; Ann Blewett; Timothy D H Bugg; Roger C Levesque
Journal:  BMC Biochem       Date:  2008-12-19       Impact factor: 4.059

8.  Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT).

Authors:  Hui Dong; Mahendra Madegowda; Adel Nefzi; Richard A Houghten; Marc A Giulianotti; Barry P Rosen
Journal:  Chem Res Toxicol       Date:  2015-12-06       Impact factor: 3.739

  8 in total

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