| Literature DB >> 9873509 |
Z Q Xu1, R W Buckheit, T L Stup, M T Flavin, A Khilevich, J D Rizzo, L Lin, D E Zembower.
Abstract
The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.Entities:
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Year: 1998 PMID： 9873509 DOI： 10.1016/s0960-894x(98)00380-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823