Literature DB >> 9873508

Conformationally restricted analogues of nicotine and anabasine.

J M Vernier1, H Holsenback, N D Cosford, J P Whitten, F Menzaghi, R Reid, T S Rao, A I Sacaan, G K Lloyd, C M Suto, L E Chavez-Noriega, M S Washburn, A Urrutia, I A McDonald.   

Abstract

A series of conformationally restricted analogues of nicotine has been synthesized and evaluated as agonists of neuronal acetylcholine receptors. Compound 2 (SIB-1663), which selectively activated human recombinant alpha 2 beta 4 and alpha 4 beta 4 nAChRs, was shown to be active in animal models of Parkinson's disease and pain.

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Year:  1998        PMID： 9873508     DOI： 10.1016/s0960-894x(98)00394-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats.

Authors:  Sanna Janhunen; Paula Mielikäinen; Päivi Paldánius; Raimo K Tuominen; Liisa Ahtee; Seppo Kaakkola
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-07-13       Impact factor: 3.000

2.  Nitrophenyl-Group-Containing Heterocycles. I. Synthesis, Characterization, Crystal Structure, Anticancer Activity, and Antioxidant Properties of Some New 5,6,7,8-Tetrahydroisoquinolines Bearing 3(4)-Nitrophenyl Group.

Authors:  Eman M Sayed; Reda Hassanien; Nasser Farhan; Hanan F Aly; Khaled Mahmoud; Shaaban K Mohamed; Joel T Mague; Etify A Bakhite
Journal:  ACS Omega       Date:  2022-03-04

Review 3.  Synthetic Methods for the Preparation of Conformationally Restricted Analogues of Nicotine.

Authors:  Biswajit Panda; Gianluigi Albano
Journal:  Molecules       Date:  2021-12-13       Impact factor: 4.411
  3 in total

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